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Conducting analysis of these formulations using a broad range of standard protein biochemistry analytical techniques for formulation selection. The candidate will also have industry based experience in a range of standard protein biochemistry analytical techniques.
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Experience with biophysical and calorimetric methodologies applied to proteins and protein polysaccharide conjugates such as Circular Dichroism, Fourier Transformed Infrared (FTIR) Spectroscopy, Fluorescence Spectroscopy, Differential Scanning Calorimetry (DSC) and Isothermal titration calorimetry (ITC) would be a distinct advantage.
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Adverum develops gene therapy product candidates designed to provide durable efficacy by inducing sustained expression of a therapeutic protein. Must have laboratory experience with a variety of analytical techniques including, but not limited to, quantitative and/or digital PCR, ELISA, and cell-based methods.
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An MS or PhD degree and experience in a bench laboratory scientific discipline such as biochemistry, molecular biology, or analytical chemistry. MS data processing and data analysis skills across a variety of key metrics such as precursors, peptides and protein counts, intensities, etc.
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Responsibilities: Establish and maintain a state of the art analytical development laboratory that will allow for rapid process development support and development of control system and characterization methods to determine potency by ELISA, as well as process related impurities including host cell protein, host cell DNA, affinity resin materials, etc.
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Extensive expertise in U/HPLC, CE, SDS-PAGE, mass spectrometry, and other analytical technologies as applied to protein analytical method development, trouble shooting and validation for GMP release and stability testing.
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Proven experience in the synthesis and evaluation of reagents for use in antibody, protein, or peptide conjugates. Extensive experience with chemistry, particularly orthogonal bioconjugation chemistry, chromatography, and analytical techniques (HPLC, MS, LC/MS, NMR.
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Work with external analytical and manufacturing CMOs to enable tech transfer and implementation of processes and analytical methods. The candidate will have had extensive experience in developing proteins, polysaccharides and/or protein conjugates formulations for vaccines, preferably vaccine systems containing adjuvants (other biological experience also considered.
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