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The ideal candidate will have expertise in protein engineering techniques, including phage, yeast, or mammalian cell display, experience optimizing expression and purification of antibody fragments (e.g. minibody and Fc-fusions) and have a working knowledge of antibody structure and function.
$122,000 - $168,000 a yearFull-timeExpandApply NowActive JobUpdated Today - UpvoteDownvoteShare Job
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Experience in multi-step organic synthesis and purification of organic compounds. Experience in chemical modification, purification, and characterization of nucleic acids (PCR, qPCR, gel-electrophoresis, enzymatic digestion, etc.
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Primary lab functions include protein expression, protein purification on a high-throughput platform, and molecular cloning. The successful candidate must have a strong protein expression / purification and molecular biology background.
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The Director of Purification Development for Pre-pivotal Biologics will be responsible for leading molecular assessment, purification development, process transfer and implementation at manufacturing facilities to produce drug substances for toxicology and pre-pivotal clinical studies.
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Skills in all or most of the following molecular biology techniques: bacterial culturing, PCR, qPCR, gel electrophoresis, Gibson assembly (design and execution), transformation (chemical, electrical, conjugative), DNA purification, Sanger sequencing and analysis, plate reader assays, fluorescence microscopy.
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Job DescriptionThe Director of Purification Development for Pre-pivotal Biologics will be responsible for leading molecular assessment, purification development, process transfer and implementation at manufacturing facilities to produce drug substances for toxicology and pre-pivotal clinical studies.
$221,170 - $286,220Full-timeExpandApply NowActive JobUpdated Today - UpvoteDownvoteShare Job
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Proficiency with the development of multistep protein purification protocols as well as characterization of purified protein complexes and protein-small molecule complexes by SPR, BLI, MST, CETSA desired as well as experience developing assays to validate and test protein function in vitro.
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Bachelor’s degree in Pharmaceutical Sciences with prior experience in peptide synthesis, purification of peptides with high-performance liquid chromatography, and characterization of peptides with mass spectrometry.
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Proficiency in the following aspects: organic synthesis, purification and analysis; experience in peptide synthesis is a plus. The individual will be responsible for synthesis, purification, and characterization of peptides and other organic molecules within our multi-disciplinary drug discovery team.
$120,000 - $140,000 a yearFull-timeExpandApply NowActive JobUpdated Today - UpvoteDownvoteShare Job
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Very strong intuition and first-principles approach to molecular biology assays, analytical chemistry tools, and NGS library prep (PCR, DNA purification, electrophoresis, etc.) Very strong intuition and first-principles approach to molecular biology assays, analytical chemistry tools, and NGS library prep (PCR, DNA purification, electrophoresis, etc.
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Experience with laboratory-scale protein purification methods such as dialysis, diafiltration, size-exclusion chromatography, and tangential flow filtration (TFF). Specifically, this will include synthesis, purification, and analytical characterization of polysaccharide-protein conjugates.
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Experience with nucleic acid purification, quantification and qualification, molecular cloning, PCR, and NGS sequencing. BA, or MS with 5+ years in molecular biology, biomedical engineering, chemical engineering, or a PhD in one of the above fields, with 3+ years of hands-on molecular biology experience in assay, product, and/or process development.
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Protein purification by means of column chromatography, viral filtration and UFDF. Protein purification by means of column chromatography, viral filtration and UFDF. Clean in Place (CIP) and Steam in Place (SIP) of fixed tanks/vessels and portable equipment and Clean out of Place (COP)/Glass wash of misc.
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Biophysics, Molecular biology (DNA purification, PCR, electrophoresis), DNA synthesis, or next-generation DNA sequencing laboratory experience. Biophysics, Molecular biology (DNA purification, PCR, electrophoresis), DNA synthesis, or next-generation DNA sequencing laboratory experience.
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Conceptual knowledge of TFF (Hollow Fiber/Cassettes) UF/DF and Column Chromatography Purification. + Work to evaluate process changes with the goal of optimizing the existing AAV downstream purification process to enhance robustness, scale-ability, and/or yield.
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purification job in Menlo Park, CA
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