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Experience with computational chemistry for discovery of small molecule ligand of protein targets. Experience with molecular cloning and recombinant protein purification. Knowledge of biochemical assays, for example mass spectrometry-based covalent protein labeling, and fluorescence-based protein-protein interaction, etc.
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The successful candidate will have a strong background in protein chemistry and bioconjugation techniques. Develop protein purification and QC protocols, including but not limited to, FPLC, HPLC, SDS-PAGE, and MS, for new reagents that are developed.
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Graduate degree in a relevant molecular discipline (organic, oligonucleotide or peptide chemistry; protein engineering) Reporting to the CSO, you will lead a team of drug discovery professionals in areas including: medicinal chemistry; DNencoded chemical library design, synthesis and screening; complex biologics (including antibody-drug conjugates, ADCs); oligonucleotides; analytical sciences; PKDM; protein sciences and structural biology.
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Bachelor’s degree in protein biochemistry, biophysical chemistry, analytical science, pharmaceutical science, physical chemistry, chemical engineering or a related field with 0-2 years of analytical or drug formulation development experience in biotech or pharmaceutical industry is preferred.
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Experience with protein/protein complex expression using multiple host systems (e.g. mammalian, insect, bacterial) and proficiency with AKTA instrumentation and a broad range of purification and protein QC techniques.
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You will support DNA encoded library production, automated synthesis, medicinal chemistry and screening compound sample needs intended to support discovery of new treatments for human disease through our protein degrader technology and innovative platforms and collaborations.
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Experience performing and interpreting high quality in vitro ADME studies, including but not limited to, metabolic stability, permeability, protein binding, enzyme induction/inhibition, transporter assays and drug interaction assessments.
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The analytical chemistry group also conducts primary research, assay development and validation, and collaborates with pongamia product teams across multiple geographies and product platforms (fuel, feed, food and bioactives.
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Support the clinical lab by troubleshooting laboratory workflows involving NGS chemistry, protein immunoassay, laboratory equipment, and informatics infrastructure. Founded in 2014, Freenome has ~500 employees and more than $1.1B in funding from key investors, such as the American Cancer Society, Andreessen Horowitz, Anthem Blue Cross, Bain Capital, Colorectal Cancer Alliance, DCVC, Fidelity, Google Ventures, Kaiser Permanente, Novartis, Perceptive Advisors, RA Capital, Roche, Sands Capital, T. Rowe Price, and Verily.
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GenScript ProBio is the subsidiary of GenScript Biotech Corporation, proactively providing end-to-end CDMO service from drug discovery to commercialization with proactive strategies, professional solutions and efficient processes in cell and gene therapy (CGT), vaccine, biologics discovery and antibody protein drug to accelerate drug development for customers.
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Some background in protein engineering, immunology, virology, and/or assay development. Strong background in protein engineering, immunology, virology, and/or assay development. PhD in Biology, Molecular Biology, Microbiology, Immunology, Chemistry, Bioengineering, or related field.
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PhD in Computational Chemistry, Medicinal Chemistry, Chemical Biology, Pharmacology, or related field. We are seeking an experienced Computational Chemist to be a founding member of our Drug Discovery Team. In this position you will work in close conjunction with our Medicinal Chemistry Team in the design and optimization of a completely novel class of therapeutics.
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In this camp, we will take a multi-disciplinary approach to learning and incorporate studies in chemistry, oceanography, ecology, and marine biology to learn about Earth's amazing seas and the animals and plants that inhabit them.
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Perform protein analysis using HPLC (size exclusion, ion exchange, reversed phase, etc), CE-SDS, PicoGreen, Capillary Western (Jess), A280, mass spectrometry, etc. Hands on proficiency and with protein analysis using HPLC, CE-SDS, Western blotting, Spectroscopy, etc.
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The ideal candidate will possess a strong background in protein chemistry and good experience in the chemical biology field. Proven expertise in protein biochemistry, and chemical conjugation techniques.
$83.03 - $87.03 an hourExpandApply NowActive JobUpdated Today
protein chemistry jobs in Emeryville, CA
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