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In this position, you will assist with the design and execution of in vivo pharmacology experiments in rodents. Investigate and validate mechanism of action of drug leads by conducting in vivo, ex vivo and in vitro pharmacology experiments.
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Effective cross-functional collaboration, especially with Institutes of Science, In Vivo Pharmacology and DMPK, in the optimization of drug leads and candidates. Strong knowledge and agility in study design and data interpretation and in the integration of Toxicology studies in the drug progression paradigm, as well as in the incorporation of safety endpoints in pharmacology studies.
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The Non-Clinical Operations Manager will support all nonclinical activities in Pharmacology, DMPK and Toxicology functions for Olema Oncology ranging from early candidate nomination, IND/CTenabling, and NDA/MAsupporting studies.
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Senior Director Clinical Pharmacology will provide leadership and implementation of the clinical pharmacology and pharmacokinetics strategies and initiatives across our early and late-stage clinical programs.
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Ph. D. in pharmacology, pharmaceutics, pharmacokinetics and metabolism, pharmacometrics, biomedical engineering, computational biology, or related field. Independent scientist with strong background in ADME and/or clinical pharmacology.
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Develop and implement new clinical pharmacology tools and technologies to drive efficient drug development. Drive execution of clinical pharmacology and quantitative sciences vision through execution, interpretation, and presentation of results to project teams, executive review and decision-making bodies.
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This research group consists of UCSF faculty whose studies are focused broadly on clinical investigation of the pharmacology and cardiovascular toxicities of tobacco, electronic cigarettes, and cannabis products.
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The Lab Coordinator will join Clinical Pharmacology Research Laboratory under the Division of Cardiology School of Medicine at ZSFG to conduct nicotine and tobacco related researches in human. The Division of Cardiology at ZSFG is home for an active clinical pharmacology research program led by Dr. Neal Benowitz, who is also an attending physician in our cardiology clinic.
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Strong knowledge of pharmacokinetics and modeling, pharmacodynamic principles, ADME concepts, bioanalytical principles, regulatory guidelines and clinical pharmacology requirements in late stage clinical development.
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Strong knowledge of a broad range of nonclinical studies relevant to drug development (Toxicology, DMPK, Bioanalytical, Biology, Pharmacology). Clinical Pharmacology and biomarker experience preferred.
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Extensive hands-on experience building quantitative in vitro assays (biochemical and cellular) and expertise with in vivo pharmacology models in an oncology drug discovery setting. Lead and collaborate with project teams to develop in vitro pharmacology strategies and support Atomwise preclinical oncology programs.
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PhD in life science-related fields (Immunology, Molecular Biology, Pharmacology, Chemistry, and Biochemistry) or Master's with 6+ years in science-related fields. Mammalian cell culture, cytotoxicity analysis and multi-color fluorescence flow cytometry.
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The position may also involve in ex vivo and in vitro pharmacology experiments. BSc, MSc in pharmacology, biology or related field with 1-5 years of post-graduate relevant experience. Experience analyzing in vivo samples (ELISA, MSD, etc.
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Should have Patent Bar membership and a background in one of the following fields: cell or molecular biology, immunology, biochemistry, bioinformatics, organic chemistry, medicinal chemistry, cancer biology, pharmacology, biophysics, or digital health-focused disciplines.
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We are actively seeking a senior patent attorney or patent agent with an advanced degree, preferably a Ph. D., in a life-science field, such as biology, molecular biology, biochemistry, pharmacology, or immunology, and at least 5 years of experience in preparing and prosecuting patent applications.
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