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Basic tissue culture and purification responsibilities include performing cell culture work, antibody purification, conjugation, and associated quality control steps including purity analysis, isotype testing, mycoplasma detection, and specificity measurement by assigned methods.
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The Research Associate will be responsible for conducting hands-on experiments including but not limited to molecular biology, mammalian cell culture, recombinant protein purification and characterization.
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Excellent proficiency in molecular biological techniques including DNA purification, molecular cloning, protein purification. Calibr-Skaggs supplements the discovery process with the required disciplines for drug development which include chemical library screening, medicinal chemistry, in-vivo model optimization, formulation development, pharmacokinetic and toxicologic expertise, and early clinical development.
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Significant expertise in protein biochemistry, including recombinant protein expression, purification and characterization is a plus. Successful candidates will be talented, highly motivated, creative individuals, able to work semi-independently, and have a strong background in either computational protein design, immunology, or protein biochemistry with an emphasis on immunology.
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The Fleet Solutions group provides turnkey overhaul / repair, testing, and parts sales for air compressors, main propulsion steam turbines, valves, steam turbine generators, auxiliary turbines, dehydrators, pumps, strainers, PLCs, blowers, and water purification.
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The successful candidate will perform a variety of techniques, including cloning and expression of recombinant proteins, tissue culture, protein purification, and preparation for mass spectrometry analysis.
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Experience with diverse purification approaches for different antibody formats, analytical characterization (SEC-HPLC, cGE, mass spec, cIEF, SEC-MALS), and developability assessment (thermal stability, poly specificity, hydrophobicity, forced degradation, serum stability) is required.
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We specialize in analytical chemistry, drug discovery and development, life science, and toxicology applications with a particular emphasis on Mass Spectrometry, LCMS, GCMS, HPLC, FPLC, liquid handling, and automation.
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Perform and train others on a variety of analytical techniques including, but not necessarily limited to: analytical balances, pH meters, high performance liquid chromatography (HPLC/UPLC), UV/Vis spectroscopy, GC, USP dissolution testing apparatus, moisture analysis by Karl Fischer, disintegration, Pion µdiss, DSC, TGA, PSD, PXRD, SEM, hardness, and friability testing.
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Design, synthesize and characterize peptides, small proteins and chemically-modified analogs using state-of-the-art synthesis, bioconjugation, purification, analytical and biophysical techniques.
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Fast-paced and collaborative environment as an Associate Scientist within the Analytical and Formulation group of Avidity’s Chemistry, Manufacturing and Controls (CMC) department. Prior experience in lyophilization formulation, cycle development, and analytical testing.
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Must have direct experience with oligo synthesis equipment (e.g., AKTA Oligopilot, AKTA Pilot/Beckman Purification systems, Dionex/Vanquish HPLC analytical systems, rotary evaporators). The main responsibility for the Synthesis and Production Microbiology Supervisor is to lead and oversee all production activities associated with oligo synthesis and production microbiology in a multi-product cGMP facility.
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Master’s degree in mathematics, physics, computer science, analytical city planning, engineering, or geography (or equivalent degree) with 2+ years of experience in transportation / network / graph modeling, quantitative analytics, data science/engineering or a Bachelor’s degree in a similar field with 4+ years of similar experience.
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Design and execute laboratory experiments to optimize and characterize conjugation chemistries and downstream purification processes for peptide-based bioconjugates. The candidate will be responsible for development and management of manufacturing and purification processes will collaborate with internal CMC groups and external CDMOs to ensure quality an on-time delivery of API’s Provides project management support for CMC programs or Chemical Development projects, may lead work streams or projects within Chemical Development.
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Experience with T-cell characterization methods (flow cytometry (multiparametric and ICS), cell-based assays (proliferation, cytotoxicity), ELISA, multiplex cytokine assays,purification using MACS system, etc.
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purification analytical jobs Company: Genomatica in Coronado, CA
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