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Laboratory research/Assay development/Automation. Co-lead with GAD the research activities & critical product profile characteristics are aligned with clinical trial expectations, such as IND submissions, and establishing Co-CMC and Co-clinical development processes.
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Experience with protein purification, molecular biology, biochemistry and/or cell-based experimental techniques is required, with a preference given to researchers with experience with assay development and high-throughput screening, high-content imaging, and/or pharmacological concepts/data analysis.
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The Scientist will provide subject-matter expertise in a range of translational research strategies, immunoassay techniques, assay development, and fit-for-purpose Regulatory approach.
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The successful candidate will be an integral member of the DST research team and work closely with various Research functions such as medicinal chemistry, structural biology, and protein therapeutics to advance transformational therapies into clinical development for patients.
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The incumbent will perform process development, assay development and validations under supervision of the laboratory Director as well as manufacture cellular therapy products for treatments of patients on clinical trials and standard of care plans.
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Our core practice areas include vaccine research, development, and production; microbiology and infectious disease research; biodefense; clinical research; global health security; and HIV/AIDS programs.
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Lead identification of assay requirements, lab selection, and contract development to ensure regulatory compliance according to GLP, GCP, and applicable global regulatory requirements such as CLIA and EU IVDR, and execution feasibility.
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Background in chemistry, biochemistry, molecular biology, virology, immunology, or related fieldKnowledge of assay development, process development, problem-solving, and statistical experimental designProtein optimization laboratory research experience preferred, particularly in recombinant protein expression.
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Design and conduct essential mechanistic experiments in cell biology, cellular biochemistry, molecular biology, and assay development. " Strong background and experience in cancer research with training in molecular and cell biology.
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Responsible for the regulated bioanalytical assay development, validation, and implementation of bioanalytical methods in the quantification of human biospecimens from clinical studies across multiple therapeutic areas/assets to support decision making.
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Conducting High-throughput assay development and execution. As a Senior Research Associate, you’ll join a team working in generative AI and synthetic biology. Senior Research Associate (High-throughput Biology.
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You will also lead and contribute to the development of new screening and automation technologies and processes, apply antibody & protein engineering expertise to design & develop novel drug discovery screening platforms, and maintain a well-developed understanding of assay approaches to drug discovery.
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These may require basic blood separation, labeling and assay methods such as ELISA, immunohistochemistry, flow cytometry, MACs bead isolations and other associated specialized laboratory methods including human iPSC tissue culture and molecular biology techniques.
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Expertise in primary human cell culture, multi-color flow cytometry, multiplex cytokine detection, functional immune cell assays (proliferation, cytotoxicity, chemotaxis) and assay development is essential.
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We have up to two openings for an Academic Graduate Appointee participating in developing novel approaches and platforms in support of synthetic biology research emphasizing cell-free protein production methodologies and vaccine development.
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clinical research assay development jobs Title: research associate Company: Adverum Biotechnologies
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