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Core areas of focus will be understanding the role of citrullination and other PTMs in the TDP -43 protein structure, biology, and pathology into both in vitro (induced pluripotent stem cell models) and in vivo systems (mouse models) to understand the clinical outcomes of TDP -43 pathogenesis in LATE and ADRD.
$56,484 - $63,852 a yearFull-timeExpandApply NowActive JobUpdated Today - UpvoteDownvoteShare Job
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We pursue a multi-disciplinary approach integrating data across biological scales in the brain, including molecular Chromosome-Conformation-Capture sequencing technologies, single-cell imaging, optogenetics, genome engineering, induced pluripotent stem cell differentiation to neurons/organoids, and in vitro and in vivo electrophysiological measurements.
$36,368 - $50,000 a yearFull-timeExpandApply NowActive JobUpdated Today - UpvoteDownvoteShare Job
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We are looking for a research associate whose primary role will focus on culturing induced pluripotent stem cell (iPSC) and performing molecular biology techniques to understand gene expression regulation during in vitro cardiac differentiation.
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We currently require a Cell Biologist to assist in projects involving the development of induced pluripotent stem cells (iPS) and novel engineered in vitro systems, such as organoids and microphysiological systems, that have high potential for predicting clinical effects of drugs in vitro.
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Contribute to the development and optimization of in vitro differentiation protocols and facilitate the production of iPSC-derived cell types, especially iPSC-derived neurons. Support development of disease phenotype-specific molecular and functional assays in relevant cell types differentiated from human pluripotent stem cells.
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Extensive knowledge of iPSC (induced pluripotent stem cell)-derived in vitro neuronal models as well as experience with exosomes as therapeutics; additional mixed cell-type culture models is preferred.
$125,000 - $165,000 a yearFull-timeExpandApply NowActive JobUpdated 11 days ago - UpvoteDownvoteShare Job
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You will develop human stem cell derived in vitro complex retinal systems. Ph. D, M.D., or M.D./Ph. D. degree in stem cell biology, neuroscience, immunology, or related field.
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The successful applicant will work with the members of the program to develop new biologics or use the existing ones to modulate the immune system for the prevention of type 1 diabetes and treatment using pancreatic islets or stem cell derived beta cells.
$55,000 - $70,000 a yearFull-timeExpandApply NowActive JobUpdated 4 months ago - UpvoteDownvoteShare Job
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Work collaboratively with stem cell biologists and disease area experts to establish complex in vitro models. The Stem Cell Biology & Genomic Editing group seeks a lab-based Senior Associate Scientist with expertise in human induced pluripotent stem cell (iPSC) culture, differentiation, and model development.
Full-timeExpandApply NowActive JobUpdated 10 days ago - UpvoteDownvoteShare Job
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Our growing research group is part of the Program in Stem Cell Biology and Regenerative Medicine in the Surgery Department. Toward that objective, we leverage human induced pluripotent stem cells (hiPSCs), cardiac directed differentiation, genome editing (CRISPR), multi-omics, 3D organoids and engineered heart tissues as developmental and disease models.
$22.03 - $24.78 an hourFull-timeExpandApply NowActive JobUpdated Today - UpvoteDownvoteShare Job
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Our team develops cutting-edge cell culture, genomics and bioinformatics technologies – to restore male fertility through the culturing of male germline stem cells, and the production of functional male gametes for clinical in-vitro fertilization.
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PhD in biomedical engineering, cell biology, stem cell biology, immunology or related field, with demonstrated understanding of human cell and tissue biology and advanced in vitro cell culture platforms.
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In vitro stem cell differentiation. Keywords: Postdoc, Research, LRI, Stem cell differentiation, NAFLD, NASH, Multicellular model, Oncolytic virus, Liver diseases, Liver organoid, Intestinal organoid, Brain organoid, Hepatitis B virus, Hepatitis E virus, Respiratory syncytial virus, Hematopoietic stem cells, Hematopoiesis, Gene regulation, Transcription factors.
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Relevant research experience in cardiac physiology, in vitro assays for drug screening applications, tissue engineering or pluripotent stem cell culture, or other relevant fields with multi-disciplinary training.
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PREFERRED: expertise integrating and interpreting multi-omics data (e.g., genomics, transcriptomics, proteomics, metabolomics); and experience with PDX models, neuro-oncology, immune engineering, cancer stem cells/neural progenitors, neurospheres or organoids or other 3D cultures, the study of electric field in tumors, recording electrical/ionic signaling from cells; experience in drug delivery, statistical analysis, genetic manipulation (cell line engineering, GEVIs, etc.
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