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In-vivo and in-vitro drug metabolism including mass balance, stability evaluation, structural elucidation, enzymology, drug-drug interaction (DDI), metabolic enzyme inhibition and induction. Develop and drive the DMPK, TK and pharmacokinetics-pharmacodynamics (PKPD) strategy for development projects to support project decisions, milestones and development candidate advancement.
$129,500 - $191,500 a yearFull-timeExpandApply NowActive JobUpdated 10 days ago - UpvoteDownvoteShare Job
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Validated ability to synthesize information from multiple scientific fields to generate insights to guide product design and development - analytical & physical characterization, in-vitro & in-vivo model systems, PBPK modeling, sensory psychophysiology, consumer research, etc.
$112,800 - $163,500 a yearFull-timeExpandApply NowActive JobUpdated 4 days ago - UpvoteDownvoteShare Job
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Responsibilities:We are currently seeking a Director, Drug Metabolism and Pharmacokinetics, who will have scientific oversight of one or more of the small molecule discovery projects and will manage the in vitro and in vivo PK, ADME and bioanalytical assays.
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The GlaxoSmithKline U.S. Drug Metabolism and Pharmacokinetics (DMPK) organization is responsible for the delivery of key DMPK support (in vitro, pharmacokinetic/toxicokinetic, and bioanalytical) that helps drive early drug discovery programs.
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General background and understanding of in vitro and in vivo pharmacology, quantitative structure-activity relationships, physics-based modeling, and simulation, and drug metabolism and pharmacokinetics pertaining to CNS drug development are desirable.
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Independently designing and synthesizing drug-like molecules utilizing medicinal chemistry knowledge and an understanding of ADME, pharmacokinetics, optimal physicochemical properties, and AI/ML predictive tools.
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We are in search of a driven Senior Principal Scientist/Associate Director specializing in the characterization of the ADME/PK properties of small molecule lead compounds and drug candidates, both in vitro and in vivo.
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Integrate data from multiple scientific disciplines across the project (e.g., biology, chemistry SAR, pharmacokinetics and ADME, statistics, experimental medicine, and clinical study design) to derive plans and in interpreting outcomes.
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The QTAS group supports Discovery and Development Projects by generating in vitro ADME data, pharmacokinetics characterization, prediction of human efficacious dose/pk and drug-drug interactions (DDI) and in vitro to in vivo extrapolations for clinical candidates.
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Solid working knowledge of Pharmacokinetics, PK/PD principles applied to modeling, ADME and clinical pharmacology concept and understanding of regulatory guidelines on DMPK/ clinical pharmacology studies to support early oncology drug development.
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We are currently seeking a Director, Drug Metabolism and Pharmacokinetics, who will have scientific oversight of one or more of the small molecule discovery projects and will manage the in vitro and in vivo PK, ADME and bioanalytical assays.
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Work with formulation development groups and provide support for activities related to formulation development, dissolution testing, in vivo-in vitro correlations and biowaivers for pre- and post-approval formulations.
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PhD in Clinical Pharmacology (or a related area such as pharmacokinetics, pharmacology, pharmaceutics) with a minimum of 10 years of experience in these areas. Work with bioanalytical team members on activities related to assay development, sample management, pharmacogenomics and biomarker development.
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The Fellow’s principle responsibility is research, which encompasses microbiology, in-vitro/in-vivo (animal) pharmacodynamic modeling, and phase I-IV clinical trials, including healthy subject pharmacokinetic studies.
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Perform quantitative LC-MS/MS (Liquid Chromatography Mass Spectrometry) analysis of small molecules from various bio-matrices in vivo and in vitro to support PK/PD, ADME, efficacy and exploratory toxicology studies.
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