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Principal DMPK Scientist
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$129,500 - $191,500 a year
Full-time
- Develop and drive the DMPK, TK and pharmacokinetics-pharmacodynamics (PKPD) strategy for development projects to support project decisions, milestones and development candidate advancement.
- Serve as DMPK and BA representative on project teams supporting the development of novel drug candidates (small molecules, possibly biologics and antibody drug conjugates) for the treatment of diseases in Oncology, and Immuno-Oncology.
- Collaborate with project team members (Project Management, Discovery Biology, Chemistry, Chemistry Manufacturing and Control, Regulatory), and groups within Translational Sciences (Bioanalytical, Toxicology, Translational Pharmacology, and Clinical Pharmacometrics) to generate relevant DMPK data to enable knowledge and data integration to inform and guide target validation, biomarker selection, and candidate advancement
- Analyze and integrate in silico, physicochemical, ADME, and DMPK data to support molecule design and selection with particular attention to the impact of drug metabolism and drug-drug interactions
- Serve as a liaison with internal and external bio-analytical groups for method development to ensure appropriate or fit-for-purpose level of qualification (non-GLP) or validation (GLP) for sample analysis to support DMPK, TK, and PKPD sample analysis.
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