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Clinical or industry experience in sickle cell disease, thalassemia, gene therapy, bone marrow transplant, or rare diseases (blood disorders). bluebird bio is seeking an accomplished and adaptable Director Medical Affairs to join the medical affairs team, focused on our gene therapy programs for Sickle Cell, Beta Thalassemia, and CALD. You will be joining a passionate and committed flock, flying closely with medical birds as well as the cross functional teams.
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Contractors) and analytical techniques to develop a comprehensive understanding of our gene-modified cell therapy products from preclinical development through commercial launch. Maintain awareness of the current state of the field (literature, regulatory expectations, and competitive surveillance), and contribute to the broader cell and gene therapy industry and academic ecosystem through publications and conference presentations.
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The Abudayyeh-Gootenberg lab (abugootlab.org) at Brigham and Women’s Hospital, Beth Israel Deaconess Medical Center, the Mass General Brigham Gene and Cell Therapy Institute, and Harvard Medical School, is seeking a highly organized and dynamic individual to serve as a Lab Manager.
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5+ years of hands-on Quality Systems experience working within a Cell and Gene Therapy or Biologics manufacturing environment. This is an exciting opportunity to lead GxP Quality Systems within a promising Cell & Gene Therapy company revolutionizing cancer immunotherapies.
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Generates and analyzes data to support lab services: ADME Toxicology, Ion Channel, Translational Biology, Cell and Gene Therapy, and Large Molecule Services. Generates and analyzes data to support lab services: ADME Toxicology, Ion Channel, Translational Biology, Cell and Gene Therapy, and Large Molecule Services.
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Areas of particular interest include gene editing, gene delivery, gene therapy, and their relevance to vision research. For example, the application of gene editing to study and address inherited retinal diseases is well-represented in the Center for Translational Vision Research (CTVR) at UC Irvine; and the development of genetic engineering technologies is well-represented both within and outside the School of Medicine, including the Schools of Engineering, Biological Sciences, Pharmaceutical Sciences, and the new Center for Synthetic Biology.
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At least two or more years of Regulatory CMC experience with AAV Gene Therapy programs is required. Develop and lead CMC Regulatory strategies for a portfolio of programs in development, including AAV gene therapies and small molecule drugs.
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Investigational medications include, but are not limited to, intravenous admixtures, chemotherapy, NIOSH group 1, 2 and 3 medications, total parenteral nutrition, oral bulk/unit dosed or prepackaged medications, compounds, cellular and gene therapy, chemicals/gases and other investigational drugs/devices.
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Significant experience with analytical development, method fit for purpose assessments including validation, and assay troubleshooting in advanced therapy medicines (lenti-viral vector, gene therapies, and ex-vivo cell therapies.
$170,000 - $205,000 a yearFull-timeExpandApply NowActive JobUpdated Today - UpvoteDownvoteShare Job
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We have built a deep portfolio of AVV-based gene therapy product candidates, with five product candidates in clinical trials: 4D-150 for the treatment of wet age-related macular degeneration (wet AMD) and diabetic macular edema (DME), 4D-710 for the treatment of cystic fibrosis lung disease, 4D-310 for the treatment of Fabry disease cardiomyopathy, 4D-125 for the treatment of X-linked retinitis pigmentosa (XLRP), and 4D-110 for the treatment of choroideremia.
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The Head of Cell Line Development will oversee the manufacturing process of novel viral vector plasmids, as well as the development of packaging and/or producer cell lines for AAV. The incumbent will lead the cell line development strategy and work cross-functionally with teams to advance the viral gene therapy pipeline.
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Precigen is a dedicated discovery and clinical stage biopharmaceutical company advancing the next generation of gene and cell therapies using precision technology to target the most urgent and intractable diseases in our core therapeutic areas of immuno-oncology, autoimmune disorders, and infectious diseases.
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The Becker lab focuses on novel therapy of acute myeloid leukemia (e.g.-RNA therapeutics or new inhibitors) and drug resistance in blood cancers (e.g.-acute myeloid leukemia, myelodysplastic syndrome) based on clinical features, mutations, and gene expression, with use of high throughput functional screening/multicolor flow cytometry to directly assay drug response.
$32 - $49.6 an hourExpandApply NowActive JobUpdated Today - UpvoteDownvoteShare Job
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WuXi Advanced Therapies is a leading global cell and gene therapy contract, testing, development, and manufacturing organization (CTDMO) that is dedicated to advancing the development and commercialization of cell and gene therapies.
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To be able to effectively promote current technical capabilities and new technologies (as they become available) to facilitate generation and closing of new clinical and commercial business opportunities in the gene therapy / viral therapy and cell therapy space.
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