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Experience in cell line development, ELISA, PBMC biomarker, cell culture, cellular assays, gene expression is desirable. Perform cell biology and molecular biology studies to support early drug discovery projects.
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Advanced knowledge of cell culture, cell line development, bioreactor operation and scale-up, centrifugation and ultracentrifugation, tangential flow and normal flow filtration.
$6,566.67 - $14,583.33 a monthFull-timeExpandApply NowActive JobUpdated Today - UpvoteDownvoteShare Job
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The ideal candidate must have excellent tissue culture skills (human cell line and stem cell culture preferred), be trained in GMP grade culture and formulation of various human cell types including peripheral blood mononuclear cells, T-cells, dendritic cells, multi potent stem cells such as mesenchymal stromal cells, pluripotent stem cells, such as human embryonic stem cells and induced pluripotent stem cells, project and personnel management skills and experience in quality control tests.
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Oversee CHO cell line development and optimization of recombinant protein expression using a variety of production formats. The primary focus of this position will be to lead the Seattle-based CMC lab function which includes CHO cell culture manufacturing, protein purification, and biophysical characterization.
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Previous experience in clinical-grade cell line development and Master Cell Bank management. Perform laboratory work in a cGMP setting, primarily working with adult cell culture (MSCs) and differentiation, following bio- manufacturing procedures and manufacturing schedules to facilitate on-time delivery of high-quality finished products for clinical use.
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Experience with the design and execution of in vivo studies to determine the effects of T Cell Engagers or Antibody Drug Conjugates on biological systems with line of sight to human safety may be considered an advantage.
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Principal Associate Scientist / Senior Principal Associate Scientist, Hit Identification And Biology
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Execute cell line engineering workflows (CRISPR, viral transduction, transfection) to support antibody discovery and screening/characterization. Dragonfly Therapeutics seeks an experienced and motivated Principal/Senior Principal Associate Scientist with a strong background in cell biology/immunology to support the discovery and development of cancer and autoimmune therapies.
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Knowledge of cell-line development for protein expression in mammalian systems and suspension cell culture. We are actively looking for individuals with passion and knowledge of upstream process development in either biologics, vaccines or in both arenas.
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Proven ability in managing projects and coordinating workflows involving cell line development and molecular biology. As the technical lead in Cell Line Development team, you'll take charge of isolating, engineering, and validating new adipogenic cell lines.
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The ideal candidate will possess a deep understanding of tissue culture, cell line maintenance, cell-based assays, and proficiency in molecular approaches such as DNA/RNA extraction and PCR techniques.
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The Vice President, BioPharmaceutical Development is a strategic leader responsible for oversight of Cell Line Development, Cell Culture Sciences, Purification Sciences, Analytical Sciences and Drug Product Sciences.
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Experience with a range of assay development in next-generation sequencing techniques, including both library preparation and data analysis. Additionally, the candidate would bring expertise in next-generation sequencing, molecular biology, and cell culture techniques to develop assays to detect on- and off-target editing outcomes and shape the next generation of therapeutic gene editors.
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The Biologics group is responsible for various functions criticalfor drug development such as: antibody discovery, molecular biology, cell line engineering,protein engineering, biophysical analytics, and functional cell assays.
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Our gene therapy platform includes Pro10, an industry-leading proprietary cell line manufacturing process, and an extensive AAV capsid and promoter library. Provide input to CDP development, in line with the Target Product Profile (TPP), for successful global regulatory approvals and market access.
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The successful candidate should have strong experience in molecular and cell biology techniques including culture of primary cells and cell lines, transient/stable transfection and cell line selection, flow cytometry, ELISA and western blot.
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