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The development and documenting of new methods or equipment for cell processing unit operations including bioreactor-based cell culture, media manufacturing, cell washing and concentration.
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The Cell Culture Development Intern will support the Cell Culture Development Group in South San Francisco, CA to work on an exciting project developing a N-1 perfusion process for Good Manufacturing Practice (GMP) applications.
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The Senior Research Associate, Bioprocess Development will be responsible for running cell and tissue culture processes as a member of the Tissue Process Development sub-team to support the development and scale-up of novel platforms for meat cultivation.
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Able to develop, revise, and review protocols or SOPs, batch records, cell culture process development and technical reports. May perform stem cell culture and differentiation, process optimization and/or scale up to improve GMP production efficiency.
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Process development and manufacturing experience includes mammalian and/or microbial cell culture and scale up, the isolation and purification of proteins, antibodies, etc., extensive experience with product recovery (depth filtration, centrifugation, MF), TFF (UF/DF), chromatography (Affinity, IonX, HPT, HIC.
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Independently execute each step of the cell line development process including plasmid production, transfection, single cell cloning, clone expansion in static culture plates and shake flasks, fed-batch analysis, and clone stability studies.
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Just - Evotec Biologics' Bioreactor Process Development group is seeking an enthusiastic and hardworking team member who is passionate about expanding worldwide access to biotherapeutics through the advancement of continuous bioprocessing technology and mammalian cell culture processes.
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The Process Development Associate will help design and perform experiments at the bench scale that span the end-to-end Drug Substance process, covering cell culture and/or purification operations.
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Process Development Engineer, Cell Therapy. + Hands-on experience with process development on primary cells, stem cells, and stem cell-derived cells, including pluripotent stem cell, mesenchymal stromal cell, T cell or NK cell.
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Support early & late-stage CMC development activities including cell line development (CLD), cell culture development (CCD), & purification development for product quantitation, product quality & process impurities for biologic molecules.
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This role will involve all aspects of cell line development from vector design/construction, cell culture maintenance, clone screening, and cell line characterization.
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This person will join a fast-paced, collaborative, and multidisciplinary team to support bioreactor process development (perfusion and intensified fed-batch) at the bench and pilot scale for the advancement of low-cost biotherapeutics manufacturing.
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Offering the world's largest cell culture media network, we provide services and products for the customer's workflow in both cell culture and cell therapy. Group/Division SummaryHeadquartered in Grand Island, New York, USA, the Cell Culture and Cell Therapy (CCCT) Business Unit is in the BioProduction (BPG) Group and the Biologicals and Chemicals Division (BCD.
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Independently execute each step of the cell line development process: Transfection Pool generation Single cell cloning Clone expansion in static culture plates and shake flasks Fed-batch analysis Clone stability studies Use automated platforms for clone selection and screening.
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As this person will be a key member of the autologous cell therapy manufacturing program, a background in cell culture, aseptic gowning and qualification, and ISO class 5 cleanroom operations is strongly desired.
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