Ionis

As the first company to fully harness the power of RNA technology for human therapeutics, Ionis' platform continues to revolutionize drug discovery and transform lives for patients with unmet needs.. This is an onsite laboratory-based role in preclinical formulations R&D for the intracellular delivery of RNA.The successful candidate will create novel nanoparticles comprising nucleic acids, lipids, polymers and peptides, perform physical-chemical characterizations, and conduct in-vivo / in-vitro studies.. Contribute to the design, production, and testing of a variety of nucleic acid containing nanoparticles for preclinical research programs and transition to clinical development.. Ability to learn and perform routine rodent procedures (eg., tail vein injection and necropsy) is required.. Experience formulating and characterizing RNA and/or protein containing nanoparticles

research associate scientist

Ionis Pharmaceuticals, Inc., is headquartered in Carlsbad, California, with offices in Boston, Massachusetts, and Dublin, Ireland.For more than 30 years, Ionis has been the leader in RNA-targeted therapy, pioneering new markets and changing standards of care with our novel antisense technology.Ionis currently has three marketed medicines and a premier late-stage pipeline highlighted by industry-leading cardiovascular and neurological franchises. Our scientific innovation began and continues with the knowledge that sick people depend on us, which fuels our vision to become the undisputed leader in genetic medicine, utilizing a multi-platform approach to discover, develop and deliver life-transforming therapies. As the first company to fully harness the power of RNA technology for human therapeutics, Ionis' platform continues to revolutionize drug discovery and transform lives for patients with unmet needs.We are building upon our innovative research and drug development excellence to provide greater value to patients, and we are well positioned financially to deliver on our strategic goals. Ionis is a challenging, motivating and rewarding environment designed to foster innovation and scientific excellence.Our success is a direct result of our outstanding employees.We are interested in bringing together a diverse group of individuals with different skill sets and perspectives into this creative environment to be part of a productive and inclusive team.While acknowledging people are actively engaged in hybrid/remote work, we continue to invest time, money, and energy into making our workplace locations a place where our culture and employees can thrive.We believe engaging on a day-to-day basis, in person,builds solid and lasting relationships, and contributes positively to our culture and innovation.From the heart of our stunning Carlsbad campus,we aim to provide a central connection point for all our employees.These facilities give us the opportunity to connect cross-functionally, collaborate and to build on the success of our business as we continue to grow.Join us and experience our unique culture while you develop and expand your career. SENIOR RESEARCH ASSOCIATE / SCIENTIST, FORMULATION AND DELIVERY SCIENCES SUMMARY: We seek inquisitive and motivated RAs/scientists to help build an exciting new gene editing franchise within a leading nucleic acid therapeutics company.This is an onsite laboratory-based role in preclinical formulations R&D for the intracellular delivery of RNA.The successful candidate will create novel nanoparticles comprising nucleic acids, lipids, polymers and peptides, perform physical-chemical characterizations, and conduct in-vivo / in-vitro studies. RESPONSIBILITIES: <ul><li>Contribute to the design, production, and testing of a variety of nucleic acid containing nanoparticles for preclinical research programs and transition to clinical development.</li><li>Produce bench scale formulations using microfluidic mixing and UF/DF, filtration, centrifugation, etc.</li><li>Perform routine rodent procedures to dose formulations and assess safety/activity.</li><li>Perform routine particle analysis via DLS, zeta potential, TNS pKa, fluorescence methods, and potentially analyze lipids and RNAs via HPLC, etc.</li><li>Proactively collaborate with scientists across the organization to advance company objectives</li><li>Thoroughly document results in electronic lab notebooks and present findings to cross-functional teams</li><li>Assist in maintaining general laboratory functionality including ordering and receiving lab supplies</li><li>Analyze experimental data and present scientific results at team research meetings</li><li>Contribute to publications and patent applications</li></ul> REQUIREMENTS: <ul><li>BS in life sciences, pharmaceutical sciences, chemical engineering, bioengineering, or related discipline with at least 3 years of relevant experience for Senior RA role</li><li>MS in life sciences, pharmaceutical sciences, chemical engineering, bioengineering, or related discipline with at least 5 years of relevant experience for Senior RA role</li><li>PhD in life sciences, pharmaceutical sciences, engineering or related discipline for a Scientist role.</li><li>Specific level will be based on each candidate's combination of skills and accomplishments.</li><li>Ability to learn and perform routine rodent procedures (eg., tail vein injection and necropsy) is required. Experience with cell culture is a plus.</li><li>Experience formulating and characterizing RNA and/or protein containing nanoparticles</li><li>Experience with analytical methods for RNA and/or lipids is a strong plus</li><li>A team player who can work both independently and with cross-functional teams in a fast-paced, entrepreneurial environment</li><li>Ability to engage experts and literature to troubleshoot complex scientific problems.</li><li>Excellent organizational and written/verbal communication skills</li></ul> Please visit our website, www.ionispharma.com for more information about Ionis and to apply for this position; reference requisition # IONIS003437 Ionis offers an excellent benefits package! Follow this link for more details: Ionis Benefits Full Benefits Link: https://www.ionispharma.com/careers/working-at-ionis/#:~:text=our%20employee%20spotlight-,Benefits,-Employees%20are%20rewarded The pay scale for this position is $86,095 to $125,690 NO PHONE CALLS PLEASE. PRINCIPALS ONLY. Ionis Pharmaceuticals, Inc. and all its subsidiaries are proud to be EEO employers.

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