Patternbio

Our headquarters are in South San Francisco, and we are building a world-class team to translate two decades of progress in DNA computing and synthetic biology into the clinic.. experimental platforms to evaluate pharmacodynamics, safety pharmacology, and pharmacokinetics of our therapeutic leads.. You will focus on evaluating the mechanism of action, biodistribution of the DNA payload and the gene products, biomarker discovery, etc.. Understanding of the regulatory landscape, preferably in the cancer gene therapy modality;. PhD in biosciences including genetics, cancer biology, bioengineering and related fields;

pharmacology

Senior Discovery Scientist, Pharmacology (Genetic Medicines) Full-Time
About Pattern Biosciences
Do you want to be at the forefront of a revolution in healthcare? At Pattern Biosciences, we build DNA computers that run molecular programs in cells to treat cancer and other diseases. Using multi-input molecular-level computation in individual cells, our approach leads to curative therapies where the conventional one drug-one target paradigm has failed to deliver effective treatments. Our headquarters are in South San Francisco, and we are building a world-class team to translate two decades of progress in DNA computing and synthetic biology into the clinic.
About the Role
Are you passionate about working with cutting-edge technologies to develop next generation therapies? You will advance the early pipeline of innovative cancer therapies harnessing our biomolecular computing platform. You will design and lead efficacy and safety studies in animal models and in sophisticated ex vivo/in vitro experimental platforms to evaluate pharmacodynamics, safety pharmacology, and pharmacokinetics of our therapeutic leads. You will focus on evaluating the mechanism of action, biodistribution of the DNA payload and the gene products, biomarker discovery, etc.
What you'll do Establish and validate in vivo and in vitro assays to generate clinically-translatable PK, PD and safety datasets that will drive clinical lead selection process. This includes qPCR-, enzymatic- and IHC-based biodistribution assays; multiplex immunoassays; immuno-PD assays; immunogenicity assessment; etc.;
Plan and execute in vitro and in vivo studies to evaluate PK/PD and safety of AAV-based therapeutic leads in oncology;
Integrate and analyze experimental datasets to delineate the mechanism of action of therapeutic leads;
Identify modes of failure and provide feedback to the design and discovery teams for iterations on the composition of matter;
Plan and manage complex projects and oversee cross-disciplinary teams;
Liaise with CROs, plan and oversee technology transfer and study execution at contract organizations;
Report study results and conclusions to the team.
What you'll bring
Excellent knowledge of preclinical assessment strategies of genetic medicines, preferably in oncology indications, with a focus on the immune mode of action;
Understanding of the regulatory landscape, preferably in the cancer gene therapy modality;
Experience in animal cancer models (syngeneic and immunodeficient models) and/or in ex vivo/in vitro models of cancer (tumor organoids, tumor explants) as well as healthy/primary human and animal cells (primary cells, microtissues, spheroids, organoids, organs-on-chips);
Knowledge of and experience in clinically-translatable in vitro immune assays, including immunogenicity assays.
Who you are
PhD in biosciences including genetics, cancer biology, bioengineering and related fields;
At least 1-2 years of relevant industry experience is strongly preferred;
Track record demonstrating creativity and passion for science and patient care;
Desire and ability to operate in a high growth environment and deliver results within specified timelines and budgets.
This is an in person role based at our headquarters in South San Francisco, CA To apply, please send a CV and cover letter to careers@patternbio.com
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