Vividion Therapeutics, Inc

The successful candidate will have extensive hands-on experience designing and executing in vivo and in vitro studies in support of target validation, lead discovery /lead optimization efforts.. PhD in pharmacology, immunology, immuno-oncology, biology or related discipline, post-doctoral experience, and 3-5 years of biotech/ pharma experience. Drug discovery experience in immunology/ immuno-oncology is strongly desired.. Design, implement, and characterize small molecules in short term studies for pharmacodynamics and pharmacokinetics, demonstrate efficacy in disease-relevant in vivo models and finally conduct ex vivo studies to define mechanism of action.. Experienced in designing, developing, performing, and analyzing in vivo/ex vivo studies, use of contemporary cellular and molecular, immunological techniques, RNA analysis, flow cytometry, protein analysis by Western/MSD/ELISA, and associated data analysis.

senior scientist

Job Description Job Description Description: *Note: exact title/level depending on experience* Company Overview: Vividion is a next generation biotechnology company based in San Diego that is leveraging its proprietary chemical proteomics platform to conduct proteome-wide footprinting of drug-protein interactions with unprecedented breadth and precision. Our technology allows us to screen, identify and optimize novel drugs that selectively bind virtually any protein, including proteins previously considered “undruggable”. Our pipeline and emerging programs reflect a matured and productive platform capable of delivering first in class drugs utilizing novel mechanisms of action (allosteric inhibitors, protein-protein interaction inhibitors, functional activators, degraders etc.) against undruggable targets in the oncology and immunology space. We are uniquely structured with opportunities for all scientists to contribute to both established programs as well as ongoing early target selection, screens and validation. We prize scientific excellence, creativity, team players and we are committed to continued innovation. We have worked hard to create a collaborative and dynamic work culture where your ideas and discoveries are valued and will have an impact. We are growing and there are opportunities for mentorship and career progression. Job Summary: Our team is seeking a highly motivated PhD Level Scientist, to contribute to the discovery and development of novel small-molecule drugs to address unmet medical needs in immune/inflammation mediated diseases. The successful candidate will have extensive hands-on experience designing and executing in vivo and in vitro studies in support of target validation, lead discovery /lead optimization efforts. The candidate thrives in a collaborative team setting and is driven by a desire to be innovative in a biotech environment.
Requirements: Education and Experience requirements:
PhD in pharmacology, immunology, immuno-oncology, biology or related discipline, post-doctoral experience, and 3-5 years of biotech/ pharma experience
Drug discovery experience in immunology/ immuno-oncology is strongly desired. Candidates in academic settings with strong accomplishments will also be considered.
Design, implement, and characterize small molecules in short term studies for pharmacodynamics and pharmacokinetics, demonstrate efficacy in disease-relevant in vivo models and finally conduct ex vivo studies to define mechanism of action.
Proven technical skills for in vivo research, including in vivo drug administration by multiple routes (such as IV, SQ, IP, IT, PO), and blood/tissue collection is required. Small animal surgical experience is a plus.
Experienced in designing, developing, performing, and analyzing in vivo/ex vivo studies, use of contemporary cellular and molecular, immunological techniques, RNA analysis, flow cytometry, protein analysis by Western/MSD/ELISA, and associated data analysis.
Excellent communication skills with the ability to work in a multidisciplinary team, mentor junior associates and colleagues and interface with CROs as needed.
Proactive, high attention to detail, excellent organizational and record keeping skills.
Mentorship skills
Proficient in Microsoft office applications, FlowJo, and GraphPad Prism
Required Key Attributes:
Candidates must have strong communication skills as evidenced in public presentations and/or peer reviewed literature.
Candidates must have effective troubleshooting and problem-solving skills.
Candidates must have demonstrated ability to multi-task, prioritize options, anticipate challenges, and execute on goals as a member of an interdisciplinary team is extremely important.
Pay & Benefits: The annual base salary for this position ranges from $125,000 to $145,000 depending on relevant skills, experience, and education. In addition, this position is eligible for target bonus, long-term-incentives, 401k retirement savings plan with company match, and a comprehensive benefits package which includes medical, dental, vision, life, and disability insurance. EEO & Employment Eligibility: Vividion Therapeutics, Inc. is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status. Privacy Policy: The protection of your personal information is a commitment we take seriously. For information regarding our Privacy Policy (CA candidates) please visit https://vividion.com/publication/privacy - noticeforcalifornia -candidates/. #J-18808-Ljbffr

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