Brigham and Women's Hospital

In vitro analyses of protein interactions that modify the barrier.. In vivo determination of barrier loss and restoration effects on disease.. A wide range of tools are used, including genetically-modified (knockout/transgenic) mice, patient biopsies, and cutting-edge microscopy approaches.. BS in biological/physical science required.. Brigham & Women's Hospital(BWH)

lab tech ii

General Summary The focus of the lab is to understand intestinal barrier loss (sometimes referred to as “leaky gut”) in Crohn’s disease, ulcerative colitis, and other immune-mediated intestinal diseases. Ongoing projects include: <ul><li> In vitro analyses of protein interactions that modify the barrier.</li><li> In vivo determination of barrier loss and restoration effects on disease.</li><li> Development and testing of novel therapies. </li></ul>Under Supervision Of PI, Work Independently To <ul><li> Manage experimental mouse colony.</li><li> Provide experimental support to other lab members. </li></ul>Hours are flexible, but will require 20 hours of work/week. The lab environment includes members from diverse backgrounds who collaboratively drive discovery and teach one another. <ul><li> Training in specific skills can be provided by current lab members.</li><li> A wide range of tools are used, including genetically-modified (knockout/transgenic) mice, patient biopsies, and cutting-edge microscopy approaches.</li><li> Continuing education occurs informally, during lab meetings and journal clubs, and through independent reading. </li></ul>Principal Duties And Responsibilities With increasing independence as skills are acquired: <ul><li> Manage breeding, maintenance, and records of mouse colony.</li><li> Tag, genotype, and transfer mice for breeding, weaning, and experimental use.</li><li> Interact with PI and others to plan and prepare for upcoming experiments.</li><li> Ensure that all necessary supplies, including mice, are available. </li></ul>Opportunities for greater experimental involvement are available commensurate with skills and interests. Qualifications BS in biological/physical science required. At least one year of experience in a related research setting (for TRA II). Skills/Abilities/Competencies Required <ul><li> Attention to detail and accuracy.</li><li> Ability to follow existing protocols and both learn and develop new methods</li><li> Willingness to or experience in handling laboratory mice.</li><li> Computer literacy, including constructing a logical search of electronic records.</li><li> Ability to identify potential problems and develop solutions.</li><li> Capable of logically and effectively structuring tasks, setting priorities, and developing/executing long-term plans. </li></ul>Primary Location MA-Boston-BWH Longwood Work Locations BWH Longwood Job Technician/Technologist/Scientist Organization Brigham & Women's Hospital(BWH) Schedule Part-time Standard Hours 20 Shift Day Job Employee Status Regular Recruiting Department BWH Pathology Job Posting Mar 25, 2024

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