AbbVie

We strive to have a remarkable impact on people's lives across several key therapeutic areas - immunology, oncology, neuroscience, and eye care - and products and services in our Allergan Aesthetics portfolio.. This internship opportunity is in the Biologics Bioanalysis, Characterization, and Disposition group within the Quantitative, Translational, and ADME Sciences (QTAS) Department which plays a key role in the in vivo and in vitro support of biologics programs via mass spectrometric assays.. Under the supervision of a Senior Scientist in the group, the individual will primarily support the establishment of a highly sensitive microflow LC-MS/MS assay for the bioanalysis of protein-based therapeutics.. Currently enrolled in a Master's or PhD program in Analytical Chemistry, Biochemistry, Pharmaceutical Science, or related field.. Familiarity with Shimadzu UPLC, Waters M-Class, and SCIEX QQQ.

disposition

Company DescriptionAbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas - immunology, oncology, neuroscience, and eye care - and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on Twitter, Facebook, Instagram, YouTube and LinkedIn.Job DescriptionQTAS Biologics Bioanalysis, Characterization, Disposition Intern OverviewEnvision spending your summer working with energetic colleagues and inspirational leaders, all while gaining world-class experience in one of the most dynamic organizations in the pharmaceutical industry. This is a reality for AbbVie Interns.This internship opportunity is in the Biologics Bioanalysis, Characterization, and Disposition group within the Quantitative, Translational, and ADME Sciences (QTAS) Department which plays a key role in the in vivo and in vitro support of biologics programs via mass spectrometric assays. Under the supervision of a Senior Scientist in the group, the individual will primarily support the establishment of a highly sensitive microflow LC-MS/MS assay for the bioanalysis of protein-based therapeutics.Key responsibilities include:* Set up initial microflow LC-MS/MS method for protein quantitation.* Optimize direct injection method and trap-elute method.* Adjust the sample preparation workflow to improve compatibility with microflow assay.* Identify the most suitable trap and analytical column combinations for the workflow.* Evaluate microflow assay robustness and sensitivity and compare to the analytical flow assay.* Draft protocols for optimized methods.* Present work (oral presentation and/or poster) to the broader department.QualificationsMinimum Qualifications* Currently enrolled in a Master's or PhD program in Analytical Chemistry, Biochemistry, Pharmaceutical Science, or related field.* Must be enrolled as a student for the duration of the internship period.* Hands-on experience with LC-MS instrumentation.Preferred Qualifications* Expected graduation date between December 2024 - July 2025.* Ability to conduct, troubleshoot, and interpret scientific experiments, providing suggestions for additional experiments, including design and development of new LC-MS assays, especially related to bioanalysis.* Demonstrate critical thinking and problem-solving skills, including data analysis.* Self-motivated; ability to execute with limited supervision and direction. Can work independently or part of a team.* Proficient in productivity & data analysis software including Microsoft Office Suite, GraphPad Prism, Sciex OS.* Familiarity with Shimadzu UPLC, Waters M-Class, and SCIEX QQQ.* Fundamental understanding of protein therapeutics (mAbs, ADCs, multispecifics, etc.) and DMPK principles.Benefits and Amenities* Competitive pay* Relocation support for eligible students* Opportunity to connect with Abbvie leaders and scientists.* Exposure to Allergan Aesthetics portfolio and Medical Device Design controlEqual Employment OpportunityAt AbbVie, we value bringing together individuals from diverse backgrounds to develop new and innovative solutions for patients. As an equal opportunity employer we do not discriminate on the basis of race, color, religion, national origin, age, sex (including pregnancy), physical or mental disability, medical condition, genetic information gender identity or expression, sexual orientation, marital status, protected veteran status, or any other legally protected characteristic.Additional InformationApplicable only to applicants

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