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Support drug candidate design optimization, selection, validation, and stability study throughout pre-clinical and clinical purification process development for antibody/protein. Ph. D.; MS in Protein Science, Biochemistry, Biophysics, or a related field (Ph. D., new graduates welcome); 5+ years (MS) of relevant pharmaceutical or biotech experience.
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Knowledgeable in molecular biology, biochemistry, enzymology, DNA, RNA and protein synthesis mechanisms. Ph. D. in Biochemistry, Molecular Biology, Synthetic Biology, Microbiology, Biomedical Engineering, or related biomedical field with a minimum of 6-year experience in the pharmaceutical company, biotech or related industries.
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Experience with upstream bioprocessing equipment, especially perfusion technology, as well as analytical or downstream purification equipment. The ideal candidate will have management and leadership skills as well as expertise in mammalian cell culture and perfusion bioreactor development for therapeutic protein production.
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Strong scientific background of recombinant protein expression, cell line development, cellular metabolism, and media optimization. Work closely with other members of Cell Science team and downstream Process Development team to develop and execute multiple projects under tight timelines.
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Perform cell-based assay to evaluate gene editing efficiency of candidate’s formulations, and maintain mammalian cell culture for research projects, and downstream cellular DNA extraction and NGS or sanger sequencing assays for data analysis.
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Experience in process development, more specifically in chemical conjugation is highly desired with a sound knowledge of organic chemistry and /or biochemistry, techniques like 1-D and 2-D NMRs, Mass spectroscopy, HPLC, HP-SEC-MALLS etc.
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General understanding of cell biology, fluid dynamics, and protein chemistry, as well as knowledge in other functional areas (upstream and analytical sciences). Leading a diverse team of scientists involved in purification process development, characterization, and validation, including technology transfer to cGMP manufacturing for hybrid and continuous processes.
$135,000 - $185,000 a yearFull-timeExpandApply NowActive JobUpdated 1 month ago - UpvoteDownvoteShare Job
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We are seeking a highly capable, enthusiastic and motivated research associate to assist in the expression of recombinant proteins using both molecular biology and mammalian tissue culture as part of the core protein expression and purification group.
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Summary: The Senior Director, Protein Engineering will be responsible for leading a group of scientists to design, engineer and characterize antibody-based drug candidates – in the format of ADC, bispecific and multi-specific antibodies.
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Experience with the design of upstream and downstream fish collection facilities, fish passage, fish screening, acclimation facilities, and aquaculture water treatment is preferred. Experience with Tribal, State and Federal fish and wildlife program managers and U.S. Army Corps of Engineers is a plus.
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We have assembled a multidisciplinary team of dedicated professionals and scientific advisors who are experts in immunology, protein science, adjuvant technology, and clinical trial and regulatory operations, to expedite vaccine candidates to market.
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BS/MS in Biochemistry, Biology, Bioengineering or related field with 7+ years of experience or Ph. D. with 3+ years of experience. Large molecule and protein characterization experience.
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Background in organic-polymer synthesis and characterization, biocompatible polymers, peptides and lipid-protein-conjugates, oligonucleotides, structure-property relationships, formulation and process development, small & large molecules, analytical separations, isolation and identification of impurities.
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Hands-on experience with analytical and purification techniques, including UV, NMR, HPLC, LCMS, and flash purification systems. Hands-on experience with analytical and purification techniques, including UV, NMR, HPLC, LCMS, and flash purification systems.
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A thorough understanding of operation and maintenance of a drinking water purification plant is required, with at least 3 yrs relevant exp. American Water partners with Seattle Public Utilities to operate the Tolt Water Treatment Facility started operations in 2001 treating water from the Tolt Reservoir located on the South Fork of the Tolt River.
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downstream biochemistry protein purification jobs in Redmond, WA
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