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Collaborate closely with chemistry and ADME pharmacology teams in closed-loop lead optimization campaigns. Leadership of the discovery biology team to in the development of strategies for internal target discovery and validation, assay development, and screening effort strategies that will drive project medicinal chemistry and deliver key elements of the development candidate project profile.
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As the Director of DMPK, you will supervise ADME scientists locally in Boston who provide drug discovery and development support for our diverse portfolio including; small molecules, biologics, nano-medicines and PROTACs∯*∯ In addition, the selected individual will also have the opportunity to provide input into drug discovery and development across the global Oncology portfolio.
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Has a good knowledge of other disciplines (e.g. Pharmacology, ADME, Clinical, etc.) PhD in toxicology, pharmacology, biochemistry, molecular biology, or related subject with focus on human health hazard and risk assessment.
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Design and execute preclinical studies to understand the pharmacokinetics (PK) and absorption, metabolism, distribution, and excretion (ADME) of drug candidates that support drug discovery, preclinical and clinical development.
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The Oncology Drug Metabolism and Pharmacokinetics (DMPK) department provides ADME/PK, as well as translational PK/PD Modeling & Simulation to support our discovery and development portfolio. You will report to the Senior Director of DMPK/ADME in Waltham US or Cambridge UK.
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