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A proven and qualified Supervisor will use knowledge and experience in upstream processing (seed expansion, bioreactor operations, cell culture harvest), downstream processing (purification and bulk filling) to teach others, troubleshoot, and continuously improve daily operations, and/or manufacturing support operations (solution preparation, assembly preparation, parts wash, and autoclave) activities.
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Combining Isolere's deep expertise in liquid phase separation, and Donaldson's filtration technology expertise, and global sales and manufacturing footprint, we are on a fast-track to develop and commercialize Isolere's novel affinity liquid phase separation reagents for biologics purification.
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The company offers a growing portfolio of purification solutions for a wide range of biologics, including AAV, lentivirus, mRNA, plasmid DNA and other viral particles. They will provide leadership and support to a team focused on the development and manufacturing of novel affinity purification products, drive day to day site operations, and ensure the Safety, Quality, Delivery and Cost of our products and processes.
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Must have hands on experience in RNA nanoparticle formulation, purification, and characterization assays in academia or direct experience in a biotechnology company. Work closely with RNA production, LNP/RNP formulation, and in vitro and in vivo team members.
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Experience with a bulk downstream protein purification process, including but not limited to Harvest, Chromatography (HIC and AEX), Buffer prep, UF/DF, and Filling. Manufacturing Steps for Downstream purification including: Buffer Prep, Homogenization, Chromatography, UF/DF, Sterile Filtration and Filling.
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He/she will maintain, train and assist students/researchers on using a 500 MHz NMR, LCMS, GCMS and Isco Combiflash Purification System instruments. He/she will maintain, train and assist students/researchers on using a 500 MHz NMR, LCMS, GCMS and Isco Combiflash Purification System instruments.
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Strong pipetting techniques requiredQualificationsSkills desired (nice to have):Knowledge of downstream purification and/or processing (experience with AKTAs / general chromatography, TFF/DFF, homogenization, etc.
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Learn aseptic techniques, cell culture, recovery, purification, aseptic fill/finish (upstream and downstream). Learn aseptic techniques, cell culture, recovery, purification, aseptic fill/finish (upstream and downstream.
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The BioProcess Engineer is responsible for assisting with organizing, running, and sustaining the manufacturing operations process at the plant/site. Entry level into the biopharmaceutical based GMP manufacturing operations, no experience necessary.
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Job DescriptionThe Manufacturing Sr Engineer I designs, specifies, installs, commissions and validates new process equipment, provides engineering technical support and troubleshooting for assigned process equipment and a GMP biological manufacturing area such as Cell Culture, Harvest or Purification.
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Demonstrated knowledge of cell culture or fermentation unit operation is preferred. Demonstrated knowledge of cell culture or fermentation unit operation is preferred. Position SummaryThe incumbent will support GMP manufacturing operations for late-phase and commercial mammalian Cell Culture programs and oversee compliance activities for the department.
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Job DescriptionJob Description: The Maurice R. Hilleman Center for Vaccine Manufacturing is located in Durham, NC. This state-of-the-art facility established in 2004, manufactures our Company lifesaving vaccines in bulk and finished forms.
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Experience executing and troubleshooting Purification equipment and processes. BioWork Certificate or Associate's Degree + at least 2.5 years of direct and/or military experience OR. Understanding of process automation and software systems (e.g. DeltaV, LIMS, etc.
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Testing performed: HLA Flow PRA screen; Luminex Single Antigen (LSA) HLA Class I & II; Flow cross-matching; ELISA; cell isolation and preservation from peripheral blood and donor tissue specimen; DNA extraction, purification, and quantitation; various molecular typing techniques to include Next-generation sequencing (NGS), RT-PCR, and low to intermediate resolution SSO/SSP typing.
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These commodities are used across the US for various needs such as fuel, fertilizers, additives in pigments, detergents, and dyes, used in agricultural industries to control weeds and create herbicides, used in canning, textiles, and even purification of water supplies.
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fermentation purification jobs in Durham, NC
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