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Strong hands-on skills in basic biochemical and molecular techniques including cell culture, quantification of mRNA (qPCR) and protein expression; ELISA, as well as assay development. The work will be predominantly with human in vitro systems, working with primary and disease tissue-derived cells.
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Serve as a member of the global Immunology, Cellular and Molecular Analytics leadership team, contributing to strategic planning and collaboration across the CMC network (including Belgium, Italy and US sites), and maintaining strong collaboration and interaction both locally and globally with internal (within TRD) and external partners (Discovery, Preclinical, GSC (Global Supply Chain), Quality, Regulatory, Universities, etc.
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A bioanalytical subject matter expert with a broad array of technical and scientific experience using a multitude of technology platforms, such as ligand-binding assays (LBA), molecular assays, flow cytometry to assess pharmacokinetics, biodistribution, pharmacodynamic biomarkers and immunogenicity.
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Additional responsibilities include: Technical support: animal handling and restraint, weaning, timed mating, tail snips, ear tagging, injections (Sub-Q, IP, tail vein), blood/tissue collections (mandibular, tail vein, term bleed: IC or RO), treatments, microinjections, surgical preparations, and post-operative observations.
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Interact with internal and external groups to provide CNS translational expertise in the evaluation of molecular and biological targets, new compounds, as well as new formulation technologies. Interact through matrixed leadership with cross-functional disciplines to incorporate translational medicine, biomarker, genomics, digital technology and quantitative pharmacology activities into development plans.
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Techniques involved will include immunological assays (e.g., tissue/cell processing, multi-color flow cytometry, ELISAs,) western blots, DNA/RNA purification and quantitation, real-time PCR, gene synthesis, mutagenesis, cloning, bacterial transformation, plaque cloning, maintenance of bacterial stocks, and tissue/cell culture.
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Our AI-designed antibodies are meticulously crafted to elicit precise molecular effects within specific microenvironments, marking a paradigm shift in biotechnology. Strong expertise in the development of biopharmaceuticals, with a background in in vitro and in vivo experimentation and functional assay development.
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2+ years of experience with recombinant antibodies and molecular biology, NGS related. Familiarity with BD FACS instruments is strongly preferred Essential Experience: 4-6 years of post-PhD laboratory experience.
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Good understanding of genomics, molecular biology, and technologies such as qPCR and next-generation sequencing. Strong background in molecular/cellular biology, immunology, and/or virology, including "bench" experience.
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Perform a variety of laboratory techniques and procedures, including handling infectious agents, performing immune cell isolations, immunohistochemistry, tissue sectioning, fluorescence and brightfield microscopy.
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Bachelor of Science in biological sciences and/or related field such as biology, chemistry, molecular biology, biotechnology, biochemistry, etc. Bachelor of Science in biological sciences and/or related field such as biology, chemistry, molecular biology, biotechnology, biochemistry, etc.
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Substantial experience with advanced molecular biology techniques (including qPCR, primer design, and NGS library preparation). This includes the design and analysis of high throughput studies using various types of “–omics” technologies such as array- and sequence-based genome-wide association studies, studies of tumor characteristics using integrated genomic data analysis, and molecular epidemiologic studies based on novel assays focused on the metabolome and microbiome.
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Express, purify, and analyze antibodies using molecular biology, protein expression, and purification techniques (e.g., PCR, cloning, transient/stable transfection, chromatography). Bachelor’s degree in Molecular Biology, Biochemistry, Immunology or related area is required.
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The Research Associate II will be responsible for performing multi-color flow cytometry and troubleshooting immunoassays. Perform multi-color flow cytometry (up to 12 colors) and be responsible for flow cytometry panel design and troubleshooting.
$85,000 a yearFull-timeExpandApply NowActive JobUpdated Yesterday - UpvoteDownvoteShare Job
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Strong hands-on skills in in vitro immunology, including immune cell isolation, culture and functional assays, basic biochemical and molecular techniques, including quantification of mRNA (qPCR) and protein expression, ELISA, Western Blotting, and Flow Cytometry assays.
$45 an hourExpandApply NowActive JobUpdated Yesterday
molecular tissue jobs Title: post doctoral fellow Company: Emory University in Rockville, MD
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