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And we're industry-leading in immunology, protein engineering and translational science. You will author, review and approve comparability protocols and reports, justification of specifications, and relevant sections of regulatory filings (IND, IMPD), and lead cross-functional teams to develop business processes and guidelines for coordinated early and late stage analytical development activities in support of biologics commercialization, including post-market life cycle management.
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Strong hands-on skills in in vitro immunology, including immune cell isolation, culture and functional assays, basic biochemical and molecular techniques, including quantification of mRNA (qPCR) and protein expression, ELISA, Western Blotting, and Flow Cytometry assays.
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As a Scientist you will have a unique opportunity to contribute to the success of company Bioscience Immunology drug discovery pipeline. It is also expected that at the Scientist level you maintain level of expertise through evaluation of scientific literature and apply and interprets principles, theories, concepts and techniques in immunology and drug discovery field.
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To address our target indications, we employ a novel self-assembling nanoparticle technology based on amphiphilic peptides called SNAP. The SNAP platform combines precision targeting of defined protein epitopes coupled with drug delivery to modulate the immune system in an antigen-specific context.
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Experience with in vitro cellular biology/immunology assays applied to physiologically relevant human cellular models, flow cytometry, multiplex cytokine measurements, activation and cytotoxicity assays, micro-physiological systems, 3D organoids, membrane protein arrays, omics technologies, confocal imaging.
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Strong understanding in multiple biochemical and molecular techniques including primary cell culture, quantification of mRNA (qPCR), multi-panel flow cytometry (including both intracellular and extracellular markers) and protein expression; ELISA, Western blot, MSD, Luminex, etc.
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Experience with protein analysis by ELISA, HPLC, Capillary Electrophoresis, or other techniques. Bachelor's degree in lab sciences such as Chemistry, Biochemistry, Immunology, Chemistry, Biology, Molecular Biology or similar.
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We want people to feel they belong at AstraZeneca and Alexion, starting with our recruitment process. Experiences with serving as an analytical lead for CMC teams and interacting with other CMC functions including process, formulation, bioassay and lot release/ stability for cross functional collaborations.
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This includes a fitness center, employee healthcare clinic, electric vehicle charging stations, dry cleaning, full-service cafeteria and copy center. Lead cross-functional team to develop business processes and guidelines for integrated early and late stage analytical development activities in support of biologics commercialization.
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Experience with protein chemistry, immunology, immunoassays, antibody-development, or technology development is preferred. Experience with protein chemistry, immunology, immunoassays, antibody-development, or technology development is preferred.
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Qualifications for the Senior Scientist include:·Master of Science in Biochemistry, Cellular Biology, Molecular Biology, Pharmacology, Immunology, Neurology, or related field is required. Small molecule, biologics, in vitro, hybridoma, protein expression, protein purification #LI-CP1 #LI-ONSITE.
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Contribute to MSD’s IP portfolio. Author or contribute to grant proposals, reports, posters and publications; act as principal investigator for externally funded projects. Ph. D. in Physical Science, Life Sciences, or Engineering.
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Main Duties and Responsibilities As a Scientist you will have a unique opportunity to contribute to the success of AZ Bioscience Immunology drug discovery pipeline. Desirable Skills: - A research background in human immunology, immune-mediated diseases (for example lupus, arthritis, intestinal bowel disease), and translational approaches to understanding basic biological mechanisms in disease is highly desired.
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