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The Animal Research Associate will be responsible for supporting all rodent in vivo studies. The Animal Research Associate will be responsible for supporting all rodent in vivo studies. 2-3 years’ prior experience working in laboratory animal research setting with rodents and using general sterile techniques.
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Supports the Antiviral Program for Pandemics (APP) and leads program initiatives from high throughput screening of small molecule compound libraries, to hit to lead and lead optimization, including in vivo efficacy studies, as part of a multidisciplinary drug discovery and development team.
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Have a thorough understanding of concepts in toxicology and pharmacology including in vivo, in vitro, and in silico test methods and familiarity with the laws, regulations, and practices related to toxicological testing.
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Knowledge of applicable complex scientific procedures and techniques, specifically with in-vitro and in-vivo model systems. Performs complex laboratory tests, determinations, and analyses involving multiple procedures and a variety of technical approaches, including those using in-vitro and in-vivo model systems.
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The primary objective of the Research Associate I, Ex Vivo is to perform cross-functional laboratory assays with a focus on in vitro/In vivo studies. Efficiently plan and execute cell line scheduling for in vivo studies.
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One such approach is In Vitro to In Vivo Extrapolation (IVIVE) which is the process of converting an in vitro concentration, associated with bioactivity, to an external exposure level, using a Physiologically Based ToxicoKinetic (PBTK) model, to determine a plausible in vivo exposure level.
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Collect both in vivo and ex vivo data; collect and maintain data using various systems. Conduct in vivo drug studies in animal models. Axle is a bioscience and information technology company that offers advancements in translational research, biomedical informatics, and data science applications to research centers and healthcare organizations nationally and abroad.
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Modeling and simulation of modified release solid oral products to ensure consistency and quality of bioequivalence (BE) recommendations (e.g., physiologically based pharmacokinetic (PBPK) absorption models, in vitro - in vivo correlations and pharmacokinetic/pharmacodynamic (PK/PD) modeling.
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Work with bio samples originating from in vivo, in vitro, ex-vivo, pre-clinical (i.e., animal) and clinical (i.e., human) studies. Draft and submit funding proposals to support novel research efforts in funding topics relevant to MRSB.Perform untargeted molecular assays to include but not limited to polymerase chain reaction (PCR), Nanostring, Western blot, ELISA, microarray, sequencing, o-link, and Lumos chromatography-mass spectroscopy.
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Can utilize TLDs for in vivo patient dose measurements and beam dosimetry. Can utilize TLDs for in vivo patient dose measurements and beam dosimetry. The Medical Physicist is responsible for computations, measurements and communication as necessary to ensure accurate delivery of radiation therapy treatments as prescribed by the Radiation Oncologist.
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At present, issues of gene and cell therapy safety assessment include: (i) a lack of physiologically relevant cellular system that can evaluate side effects of genome editing tools on genome and epigenome, (ii) demand for in vitro cellular assay to determine effect of editors on stem cell differentiation and proliferation, (iii) demand for development of robust and sensitive in vivo assays of RNA editing.
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Culmen International is hiring an In Vivo Laboratory Technician II to provide support for the Walter Reed Army Institute of Research Experimental Therapeutics Program and will be onsite in Silver Spring, MD.
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Previous experience in a laboratory setting with in vitro and in vivo models, and a willingness to learn new techniques required. Previous training with basic techniques such as HPLC, Cell Culture, Western Blotting, Elisa, and PCR preferred.
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Skillsets include cell culture models, molecular assays, and in vivo models. A working knowledge of in vitro cell culture models (3-D, organoid), genetic modifications (siRNA, shRNA, CRISPR), DNA damage repair, immunoassays (multiplex ELISA), and multi-omics (genomics, transcriptomics, proteomics, epigenomics) is required.
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Generate, interpret, and communicate in silico data, and communicates data with the department lead as well as with project teamsContribute to the overall computational antibody strategy for multiple new drug R&D projects and play an active part in its implementationCollaborate with experimental researchers to validate and optimize designed antibodies through in vitro and in vivo assays.
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vivo job Company: Genoskin in Bethesda, MD
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