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Extensive hands-on experience in protein purification techniques, including affinity chromatography, size-exclusion chromatography, ion exchange chromatography, and hydrophobic interaction chromatography.
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The Senior Scientist I will play a key role in the developing downstream purification process development for various modalities such as mAbs, ADCs, bio-specifics, gene therapy, etc. Develop recovery and purification process that utilizes clarification, chromatography, and membrane filtration technologies for monoclonal antibodies, bio-specifics and antibody drug conjugates (ADC.
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BS, MS, or PhD in Protein Chemistry (or equivalent i.e. Chemical Engineering, Biochemistry Biophysics, Pharmaceutical Sciences) with 5+ (BS), 1+ (MS), or 0 (PhD) years biopharmaceutical industry preferred.
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The candidate will be involved with all aspects of protein purification and protein chemistry to support biopharmaceutical process development. Will develop economical, robust steps for recovering the target protein from bioreactor harvests using chromatography, filtration, and other separation techniques; developing downstream purification processes to be transferred to Manufacturing; and performing laboratory scale process characterization studies.
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Operate liquid handling systems (Protein Maker, Hamilton) to perform high-throughput sample preparation and purification. Perform protein analytical assays, including Affinity Chromatography, SEC, CEX, CE-SDS, icIEF and LC/MS to support rapid process development.
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Conducting design review including specifications, procurement, fabrication management, and installation of equipment, facilities, and utilities related to the manufacture of biologics bulk drug substance including basic unit operations involving fermentation, cell culture and protein purification and related equipment.
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A successful candidate would hold a BS in a biological science (cell biology, genetics, biochemistry, molecular biology, etc. Train on IACUC, IRB, EHS, Radiation safety protocols. Train on IACUC, EHS, Radiation safety protocols.
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Background in organic-polymer synthesis and characterization, biocompatible polymers, peptides and lipid-protein-conjugates, oligonucleotides, structure-property relationships, formulation and process development, small & large molecules, analytical separations, isolation and identification of impurities.
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The ideal candidate will hire, train, and manage a team of five operating a biomanufacturing service that covers processes in cell line development, bioreactor operations (1L, 1L, 20L to 100L scales), downstream purification, analytics, quality studies, and reporting.
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Working knowledge on protein purification and hands-on experience on chromatography workstations preferred. Conduct a wide range of biochemistry, molecular and cellular biology techniques to express, purify and characterize drug candidates (e.g. DNA/RNA isolation, plasmid construction, PCR, Octet, HPLC, mammalian cell culture, transient and stable transfections.
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At The Trustmark Companies we help people thrive.
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Prepares protein according to standard recipes by seasoning, grilling and cutting into appropriate portions as designated, and storing properly for anticipated usage. Bertuccis is an equal opportunity employer.
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The ideal candidate will function in a cutting-edge laboratory environment as part of a multi-disciplinary team of protein engineers, immunologists, molecular biologists, and protein biochemists to discover novel therapeutics with opportunity to develop cGMP or GLP compliant skills in an industrial laboratory setting.
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Experience with protein purification and in vitro analytical techniques for protein characterization (e.g., SEC, MS) Other desirable skills include experience with high-throughput platforms for protein expression, purification, and analytics.
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Facilitate and support the analysis, administration and oversight of air, water and soil samples using standard chemistry/ biochemistry policies, programs, and practices. Bachelor’s degree in Chemistry/ Biochemistry or a closely related field, or an equivalent combination of education, training and experience.
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biochemistry protein purification jobs in Worcester, MA
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