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Provide assistance in the execution of experiments and analytical procedures including: molecular biology, DNA cloning, cell culture, protein production, ELISA, Biolayer interferometry and HPLC.
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Experience with basic immunoassays: ELISA, Western Blot, IHC, etc. The first is discovery and validation of novel antibody (Ab) shuttle compounds that can greatly enhance the transport of therapeutics across the BBB to the brain.
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In vitro phage library panning and clone screening via phage ELISA and periprep ELISA. pool DNA cloning from antibody discovery outputs. nanopore sequencing of antibodies and antibody fragments.
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Proficiency in a variety of bioanalytical techniques including, but not limited to, ELISA, MSD, HTRF, flow cytometry, qPCR, NGS, mass spectrometry, and cellular imaging techniques. Prior industry experience in drug discovery or preclinical development is required, and focus on immunology, metabolism and antibody development is required.
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We are looking for a talented Scientist to support the discovery and validation of our antibody brain shuttles and to lead the development of our brain shuttle-mediated oligonucleotide platform.
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