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The successful candidate will play an integral role across our oncology research groups, overseeing the development of relevant in vivo animal and cell models, and the design and execution of pharmacology studies to propel our pre-clinical research and early development oncology pipeline in addition to Translational initiatives, such as in vivo combination evaluations.
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The successful candidate will use their strong in vivo pharmacology background and complementary laboratory skills to support discovery efforts and established pipeline projects with an emphasis on anti-obesity therapeutics.
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Plan and independently implement in vivo studies and in vivo assay development and optimization to support preclinical characterization and evaluation of targets/pathways that regulate energy balance.
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You will be responsible for the development and execution of short and long-term medical plans supporting ex vivo cell therapy programs in both immuno-oncology and autoimmunity and aligning them with overall business goals.
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Collaborate with Protein Sciences to optimize the developability profiles of candidate molecules, and with In Vivo Pharmacology team to evaluate PK/PD, efficacy, and toxicity. Enthusiastic about playing a pivotal role in the dynamic and multidisciplinary environment of a small biotech, specifically within the realm of in vivo sciences.
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Hands-on experience establishing and optimizing in vivo pharmacology models and assays. Knowledge and experience in pre-clinical in vivo imaging (PET, SPECT, MRI, or CT) including understanding of theory and applying imaging to the study of disease in one or more therapeutic areas to study drug effects, biodistribution, and target engagement.
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Be a thought partner providing scientific input for in vivo preclinical toxicology studies. PhD + 5 years' experience in toxicology or other closely related life sciences field, in the industrial or CRO setting, executing, or managing in vivo studies for the purpose of advancing a biological therapeutic candidate into the clinic (BS +11 years or Masters + 9 years will also be considered.
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Collaborate with high throughput biology, cell modeling, medicinal chemistry, and in vivo pharmacology to advance projects from hypothesis to IND-enabled programs. Reporting to the Head of Hematology Discovery, the Sr. Research Associate / Associate Scientist in Hematology will be a highly innovative and driven scientist who is dedicated to transforming the lives of patients living with hematological diseases.
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Collaborate closely with other groups within the early CVRM therapeutic area to provide expert clinical input into pre-clinical scientific activities such as target selection, lead generation and optimization, clinical pharmacology, in vivo animal studies, in vitro studies, and drug formulation and manufacturing.
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Strong in vitro and in vivo translational experimental design and bioanalytical method development background. Required: M.S. with 5+ or Ph. D with 2-4+ years of applicable industry experience in Immunology, Cell Biology, Pharmacology, Pharmaceutical Science, or other relevant disciplines.
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Our pathologists are empowered by access to AI digital pathology, multiplex assays, advanced molecular imaging techniques, and a full suite of in vivo imaging technologies. Are you a passionate veterinary anatomic pathologist interested in driving innovation in drug discovery to bring safe and effective therapies to cancer patients.
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Ampersand is currently seeking an experienced leader with deep expertise in drug development to head our In Vivo Pharmacology team. The ability to collaborate closely with the leadership team and other R&D leaders while guiding the in vivo pharmacology team to achieve the company's objectives is an essential element of the role.
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Program Team Leader, Ex Vivo Cell Therapy ProgramAccountable for the achievement of program milestones in scope, time, budget together with sub-team leads and functional leads that is aligned with corporate strategy.
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At 1910 Genetics, we put computation at the heart of drugdiscovery, blending expertise in computational chemistry, structuralbiology, pharmacology, genetics, data science, and softwareengineering to develop drugs for previously undruggable targets.
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Murine tumor models and study protocols, ensuring compliance with regulatory, ethical, and quality standards; including serving as Principal Investigator on internal in vivo pharmacology protocols.
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pharmacology in vivo jobs in Waltham, MA
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