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As part of the Discovery Biotherapeutics efforts at BMS, the Principal Scientist will play a key role in advancing antibody drug conjugates technologies at BMS. The candidate is expected to have strong collaborative skills to ensure robust partnerships with biologists, antibody discovery and engineering & bioanalytical scientists to advance ADC projects.
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This position offers a unique opportunity to work in a dynamic and innovative environment developing your career at the interface of mechanistic research, drug discovery, and preclinical drug development.
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Possessing in-depth knowledge of antibody-based discovery, optimization/ engineering using in vivo based discovery methods that include transgenic animals/ llamas and single B cell cloning methodologies and NGS to manipulate and mine antibody populations appropriately for therapeutic antibody workflows.
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Strategically devise and implement in vitro antibody discovery approaches utilizing hands-on laboratory techniques, including both naïve and immune repertoires in yeast display platform. A good knowledge base in the field of in vitro based antibody discovery and engineering, specifically using a yeast display platform, as demonstrated by several years of hands-on technical know-how for multiple targets.
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We have developed a drug-discovery platform that integrates computational chemistry, structural biology, chemical biology, target-informed screening, and mechanism-driven pharmacology to develop small-molecule therapeutics that specifically modulate ferroptosis, a newly discovered form of programmed cell death.
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The Mechanism of Cancer Resistance (MoCR) Thematic Research Center (TRC) is seeking a highly motivated Associate Scientist to support Discovery Biology research programs at our facility in Cambridge, MA. The ideal candidate will contribute to our discovery pipeline from the bench by taking responsibility for developing, optimizing, and troubleshooting cellular assays to characterize and advance novel molecules of interest.
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Job Description : The Mechanism of Cancer Resistance (MoCR) Thematic Research Center (TRC) is seeking a highly motivated Associate Scientist to support Discovery Biology research programs at our facility in Cambridge, MA. The ideal candidate will contribute to our discovery pipeline from the bench by taking responsibility for developing, optimizing, and troubleshooting cellular assays to characterize and advance novel molecules of interest.
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Our antibody discovery services team seamlessly integrates our proprietary in vivo, in vitro and in silico platforms to collaborate with others to discover and optimize antibody-based therapeutics.
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Position Description:The Neurophysiology Group within the Research and Development organization is searching for an experienced electrophysiologist to support novel drug discovery research in CNS disorders.
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Join Takeda as a Senior Scientist where you will use state-of-the-art discovery technology and creating novel treatments to make a large impact on patients’ lives in the fields of Oncology, Gastroenterology and Neuroscience.
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Collaborate within the Discovery team on biochemistry and biophysics projects and provide cell biology expertise and guidance to junior team members. Lead cell biology efforts within the Discovery team to identify and implement relevant cell-based assays for diverse target classes and disease areas (immunology, oncology, metabolism.
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Schrödinger, a leader in computational chemistry software and services for customers in the preclinical drug discovery space, is seeking an ambitious, highly driven, and goal-oriented Senior Account Director to work on the Strategic Account team.
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In this leadership role, the machine learning research fellow will lead the development and application of machine learning and artificial intelligence across applications in global research, preclinical, and pharmaceutical sciences to improve, advance, and accelerate the discovery and development of transformative small molecule medicines, cell therapies, and genetic therapies.
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Who will love this job: A highly successful account manager who’s deeply familiar with computational chemistry software and/or pharma/biotech software solutions and the drug discovery processes.
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This team is searching for a Principal Scientist, ADME. You will be collaborating with the Preclinical and Analytical Sciences group, to manage ADME lab operations and support small molecule drug discovery programs for cardiovascular indications.
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discovery job Title: fellow in Waltham, MA
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