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Key Responsibilities Include:Establish in vivo screening cascades for new ocular therapeutics. Experience in handling samples from in vivo studies is required. Education, Registration & Certification:A PhD or master's degree with extensive experience in ophthalmology Experience:Experience with vivarium responsibilities including non-clinical ocular imaging, animal handling, intravitreal injection, eye dissection, perfusion is required.
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Establish in vivo screening cascades for new ocular therapeutics. Basic wet lab skills, including but not limited to, molecular biology and biochemistry techniques such as DNA and RNA extraction, lysate preparation, qPCR, protein quantification, Western blot/WES/JESS, and ELISA is preferred.
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Experience with in vivo models of oncology or immune-related diseases is highly desired. Responsibilities will include: Independently design, plan and execute in vitro and ex vivo cell-based immunoassays to demonstrate proof of concept and generate mechanistic understanding of therapeutic candidates.
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Manage development of in vitro and in vivo models to enable new target selection and characterization, and biomarker identification. Degree should be in Immunology, Virology Molecular Biology, Microbiology, Cell Biology or applied science field based on the specific requirements of the job function.
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Work closely with the formulations, informatics, analytical methods, in vivo , process development, and RNA synthesis teams to integrate novel lipid chemistries into an overall pipeline of delivery vehicle construction, deployment, and in vivo studies.
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The ideal candidate will have neuroscience research experience employing a variety of in vitro/in vivo electrophysiology techniques including traditional whole-cell patch-clamp, extracellular field potential recordings, and qEEG. Additional computational or programming experience is also required.
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Our portfolio, spanning from in-vitro and in-vivo diagnostics to image-guided therapy and innovative cancer care, is crucial for clinical decision-making and treatment pathways. It is Siemens Healthineers’ policy to comply fully and completely with all United States export control laws and regulations, including those implemented by the Department of Commerce through the Export Administration Regulations (EAR), by the Department of State through the International Traffic in Arms Regulations (ITAR), and by the Treasury Department through the Office of Foreign Assets Control (OFAC) sanctions regulations.
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At least 1 first-author publication (published or manuscripts submitted for publication) in high-quality specialty or general readership journalsExperience in in vivo disease models, tissue harvesting, dissociation, and cell isolation.
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Experience designing and interpreting in vitro and in vivo studies exploring mechanisms of toxicology involving biochemical, immunological, functional, molecular, and/or structural endpoints. Family care services such as adoption and surrogacy reimbursement, fertility/infertility benefits, support for traveling mothers, and child, elder and pet care resources.
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Represent DMPK function on project teams; oversee and integrate all In Vitro and In Vivo ADME, PK, and PK/PD efforts for discovery and preclinical development programs. Represent DMPK function on project teams; oversee and integrate all In Vitro and In Vivo ADME, PK, and PK/PD efforts for discovery and preclinical development programs.
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O Participate in sample collection of murine and human tissues, including the preparation of tubes, interfacing with in vivo scientists to retrieve samples, isolation of primary immune cells, and standard mammalian cell culture.
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Job Overview: This job requires partnering with various project teams, setting DMPK strategy, and driving execution of projects in the pharmaceutical industry, utilizing strong expertise in PK/ADME strategies, PK and PK/PD modeling, and excelling in a collaborative and fast-paced team environment.
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This role presents an exciting chance to leverage your scientific knowledge in pioneering experiments designed to pinpoint and authenticate novel immunological/oncology targets through both in vitro and in vivo humanized models.
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Evaluate the pharmacology of lead small molecules in-vitro and in-vivo in biological systems using different molecular imaging approaches. We are seeking a results-oriented scientist with expertise in plate-based and tissue-based pharmacology techniques using radioligands in in-vitro and in-vivo biological systems.
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Alloy’s Translational Research team supports our drug discovery partners with in vitro and in vivo testing of therapeutic drug candidates across multiple modalities. Family planning support up to $45,000 (e.g., IVF/PGT, adoption, surrogacy, egg retrieval.
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