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The Scientist hired will play a key role in the development of editing technology to support our in vivo sickle cell editing program. Through application of synthetic biology techniques, rationale design and genetic screens the successful candidate will develop novel editing technology.
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You will be an SME for genotoxicity and gene editing products working closely with Computational Biology, Toxicology, Genomics Innovation and PreClinical Genotox to support the development of genome editing based therapeutics into the clinic.
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Prior experience interpreting and implementing regulations and guidelines governing publications and scientific communications (e.g., FDA, OIG, GPP, ICJME, MALR) Agios Pharmaceuticals is searching for a dynamic Director, Global Scientific Communications and Publications tojoin our growing Global Medical Affairs team.
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Lead assay development and implementation to demonstrate gene editing and impact on target expression in relevant human cell lines and primary human cells in vitro and target tissues in vivo. The ideal candidate will have a diverse in vitro and in vivo experimental skill set with a strong background in primary cell culture and molecular biology, a track record of creative thinking, and a deep interest in genome editing.
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Design and execute CRISPR-based genome editing experiments to generate cell lines with specific mutations for target validation and drug screening applications. We are seeking a highly skilled and motivated Ph. D. Scientist with expertise in CRISPR genome editing to join our innovative research team.
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Job #19582 Candidate selection will be made through an evaluation of experience in genetic engineering of yeast and/or bacteria, the quality of publications in areas relevant to the posted research requirements, record of accomplishments entered into the candidate’s CV, descriptions of research and educational experiences provided in the application materials, and the strength of professional references.
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Publications (including first author publications) in leading computational biology conferences and / or in leading computational biology, bioinformatics, genomics, or multi-disciplinary journals are a plus but not required.
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Through the application of gene editing and synthetic biology, we aim to enhance T-cell fitness to overcome the immunosuppressive tumor microenvironment, with the goal of inducing long-term responses in patients with solid tumors.
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Members of PTI will be supported with industry-level resources to lead research projects and disseminate their discoveries and innovations to the broader biomedical community through frequent publications, presentations, and submissions to public data portals.
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Doctoral degree (Ph. D.) focused on synthetic organic chemistry or medicinal chemistry with 3+ years of experience in biotech and/or pharmaceutical industry setting (OR M.Sc. degree focused in synthetic organic chemistry with 8+ years of experience), and a strong track record of scientific innovation and success documented through peer-reviewed publications and patents.
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Work closely with representatives from different therapeutic areas, as well as those from Editing Technologies, Tissue and Cellular Imaging, Genomics and Computational Biology, Pharmacology, Toxicology and Program Management groups to coordinate workflows.
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Additional preferred skills include experience with CRISPR-based gene editing techniques, and primary T cell culture and editing. The ideal candidate should have relevant experience in mammalian tissue culture, lentivirus and retrovirus-based cell transduction and engineering, qPCR and basic flow cytometry, and enjoy a fast-paced, collaborative, and vibrant startup culture.
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Strong editing, writing and oral communication skills. Reporting to and working closely with the Dean of Students, Director of the ARC, Director of Student Life and Student DEI, and the Director of Student Accessibility Services, the DOS Operations Coordinator/Program Manager is responsible for the planning, marketing, and implementation of programs and events to advance the mission and goals of the DOS Office.
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Knowledge and experience with Civil 3D, Geopack, and 3D model space editing software a plus. Perform simple plan editing and reviews rough sketches, drawings, specifications, and other engineering data received from Senior Technicians and Engineers.
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The research studies focus on the elucidation of molecular and cellular mechanisms underlying stem cell self-renewal, cell fate determination and differentiation, crosstalk of signaling pathways, tissue repair and regeneration, and stem cell-based and gene-editing therapies.
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publications editing jobs in Needham Heights, MA
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