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The GNAT ED unit currently focuses on bringing compounds utilizing RNA interference (RNAi) technology into and through early clinical development. Works with the VP GNAT ED, and early clinical development functions including Non-Clinical Research, Bioanalytics, Clinical Operations, Medical Writing, Program Management, CMC and Regulatory Affairs.
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Prior experience in RNA therapeutics and rare disease indications is highly desirable. Korro Bio, a publicly traded biopharmaceutical company, pioneers the frontier of genetic medicine by harnessing the power of RNA editing.
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Primary responsibilities would include but not limit to molecular cloning, small-scale RNA production and purification. The ideal candidate will work closely with molecular biologists, RNA biologists, process engineers and chemists to support the development of self-amplifying mRNA (sa-mRNA) platform technology and process.
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Utilize deep knowledge of immunohistochemistry (IHC) and IHC processes in a regulated environment. Utilize deep knowledge of immunohistochemistry (IHC) and IHC processes in a regulated environment.
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Lab experience in purification of proteins and/or DNA/RNA using column chromatography (e.g., Ion exchange, Hydrophobic Interaction, and/or Reversed phase) and UF/DF. Some hands-on experience in analysis of proteins or DNA/RNA, preferably using both HPLC and UV/Vis spectroscopy.
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Ability to develop, evaluate, and implement workflows for technology, optimize and standardized existing techniques and workflows with respect to experimental HT mRNA generation process workflow including DNA & IVT-RNA production, and in vitro/in vivo screening is desired.
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Knowledgeable with protein and/or RNA LNP analytical characterization techniques including but not limited to aSEC, iCE, CGE (Labchip, TapeStation, Fragment Analyzer), qPCR, DLS size/PDI analysis.
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The Cancer Research Institute's researchers are responsible for breakthroughs across the spectrum of cancer science, from genetics to signal transduction to RNA medicine and beyond. BIDMC, a founding member of the Dana-Farber/Harvard Cancer Center, is a major recipient of funding from the National Institutes of Health.
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Primary responsibilities include execution of immunohistochemistry and histology experiments to support the identification and validation of Client targets to treat CNS diseases including neurodegenerative diseases.
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Carries out genomic (DNA, RNA) analyses by high-throughput sequencing, protein analyses by immunoblotting, and drug response assays. Carries out genomic (DNA, RNA) analyses by high-throughput sequencing, protein analyses by immunoblotting, and drug response assays.
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The Neuroscience team is seeking a motivated and technically skilled in-vitro scientist with established immunohistochemistry expertise in Neuroscience to join our Boston-based Exploratory Discovery team.
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As a Research Product Manager for RNA Assays and Products at Tempus, you’ll be on the front lines of our battle to develop and deliver cutting-edge, modern technology into the hands of clinicians.
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This is an exciting opportunity for BS, MS, and PhD level individuals with immunology, cell biology, and/or molecular biology experience to learn and execute key techniques including culturing primary human cells and cell lines, CRISPR editing, biochemical assay development, ELISA and other cytokine-based assays, RNA isolation and quantitative PCR, and flow cytometry/FACS and microscopy.
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Workflow including DNA & IVT-RNA production, and in vitro/in vivo screening is desired. Working knowledge of nucleic acids DNA/RNA analytical performance assessment tools: PCR, Cloning/plasmid generation and design, Quality control on DNA/RNA (capillary electrophoresis, UV quantification, Sanger sequencing, NGS.
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Histological studies, including immunohistochemistry. Preparation and analysis of DNA and RNA. A research technician position is available in the laboratory of Dr. Eva Liu in the Division of Endocrinology.
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immunohistochemistry rna jobs in Medford, MA
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