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Thorough working knowledge of in vivo techniques and animal model used in a biopharmaceutical R&D setting, including familiarity with various therapeutic modalities such as small molecule therapeutics, cell therapy, and gene therapy.
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Potentially in vivo evaluation of the sensitivity of different lung cancer models to targeted therapies, including establishment of tumor xenografts, drug treatment, assessment of tumor response and harvesting of tumor tissue.
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The candidate is expected to participate in in vivo non-human primate protocols. PRINCIPAL DUTIES AND RESPONSIBILITIES: Provide clinical support services at the Center for Transplantation Sciences (CTS), including post-procedural recovery, restraint, and drug treatments of in vivo subjects as needed.
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The projects will have a dual focus on performing in vitro mechanistic studies in triple negative breast cancer cell lines and in vivo studies using mouse models of triple negative breast cancer.
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Collaborate closely with other groups within the early CVRM therapeutic area to provide expert clinical input into pre-clinical scientific activities such as target selection, lead generation and optimization, clinical pharmacology, in vivo animal studies, in vitro studies, and drug formulation and manufacturing.
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We are a diverse team of experienced physicians and clinical scientists who collaborate to delineate early phase clinical development strategies, design innovative phase I-IIb clinical trials, develop and validate novel surrogate endpoints, and translate scientific ideas to proof of concept studies in targeted patient populations.
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We are recruiting a Scientist II/Sr. Scientist I with experience in phase-appropriate analytical method development, optimization, and qualification of physicochemical assays for lot release, stability, and characterization of cell and gene therapy products to support Beam's in vivo programs using lipid nanoparticle (LNP) delivery.
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Experience with the designing and performing assays for non-Standard Amino Acid proteins in in vitro or in vivo. Strong understanding of fundamental concepts in protein therapeutics and in vivo delivery preferred.
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This includes hands-on experience in vitro cell-based assays, flow cytometry, and/or in vivo studies, This may be exemplified by a productive PhD or postdoc and/or industry experience.
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The ideal candidate will be contributing towards in vitro / in vivo BA and biomarker (BM) quantitation studies along the drug discovery path using cell-culture, quantitative bioanalysis and related lab skills, especially for early-stage programs in the company portfolio.
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A successful candidate will have had experience with preclinical drug discovery including immunoassays, flow cytometry, cell cytotoxicity assays, and ex vivo cell-based assays. PhD in Immunology, Biology, Biochemistry, or related life science field with proven hands-on experience with 5-10 years of industry experience.
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To analyze neural circuit structure and function at highest resolution and completeness possible, we combine large-scale structural and functional imaging techniques including high-throughput electron and X-ray microscopy, and in vivo two-photon calcium imaging.
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Previous experience with CAR-T, CAR-NK, CAR-γδT, TCR-T cell immunotherapies, including cell culture, immune cell activation/expansion, viral transduction in vitro and in vivo immune cell characterization and function assessment, such as, multi-color flow immunophenotype, multiplex cytokine measurement, cytotoxicity assay is a plus.
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The In-Store Shopper not only helps our online customers but those in our store as well. A Day in the Life:As the In-Store Shopper you will have the opportunity to be the best and select “the best of the best” for our online shoppers.
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TravelNurseSource is working with AMN Healthcare to find a qualified OR RN in OAK BLUFFS, Massachusetts, 02557! Your presence in these communities contributes to filling critical gaps in healthcare services.
$2,666 a monthFull-timeExpandApply NowActive JobUpdated 5 days ago
in vivo jobs Company: Genoskin in Lynn, MA
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