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Expertise in primary human cell culture, multi-color flow cytometry, multiplex cytokine detection, functional immune cell assays (proliferation, cytotoxicity, chemotaxis) and assay development is essential.
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Deep expertise and industry experience in cell therapy process development principals including DOE and experience with current technologies in PSC process development and manufacturing, particularly scalable stem cell culture systems such as bioreactors.
$290,000 - $340,000 a yearFull-timeExpandApply NowActive JobUpdated Today - UpvoteDownvoteShare Job
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A minimum of 10+ yrs hands on experience in Process Development of cell therapy and/or gene therapy products. We provide process development, produce GMP viral vectors, and provide cell transduction for gene and cell therapy clinical trials and are proud to be a part of the process that leads to new cures.
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The successful candidate will assist to develop a first-class suspension cell line development platform for high-quality non-viral drug delivery vehicle production, including both transient transfection and stable producer cell line effort.
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Job Title: Postdoctoral Fellow Location: Cambridge, MA Duration: 12 months on Contract Description: Highlights: Strong Molecular Biology Description The Biological Process Development recently has Cell Line Development (CLD) group is responsible for producing cell lines that express clinical grade therapeutic proteins and viral vectors for Cell and Gene Therapies.
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Transient cell culture techniques such as transfection, cell number and viability monitoring, cell lysis and protein harvest Purification of proteins using liquid chromatography techniques.
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Extensive hands-on experience with standard immunological techniques including multi-parameter flow cytometry, cell sorting, immunoassays such as ELISA, Cytotoxicity, in vitro co-culture assays (MLR, PBMC cultures, etc), and reporter bioassay development.
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The Translational Team provides robust functional characterization of biologics including monoclonal antibodies, multispecific antibodies, TCR- mimic antibodies, chimeric antigen receptor (CAR)-expressing cell therapies and genetic medicines, among others.
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Department/Area Stem Cell and Regenerative Biology Position Description The Arlotta lab at HSCRB is working to identify the cellular and molecular pathways disrupted in brain disorders such as schizophrenia and autism, by utilizing recent advances in genetics and genomics.
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Benefits include Associate discount; 401(k) match; medical/dental/vision; HSA; health care FSA; life insurance; short/long-term disability; paid holidays/vacation /sick/bereavement/parental leave; EAP; incentive programs for management; auto/home insurance discounts; tuition reimbursement; scholarship program; adoption/surrogacy assistance; smoking cessation; child care/cell phone discounts; pet/legal insurance; credit union; referral bonuses.
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Understands financial markets (e.g. M&A, large Corporates, Liens and Loans, Banking, Capital Markets, Alternative Investments) Experience working with cross-functional technical teams including Customer Service, Product Management, Development, Sales, Pre-sales, legal, and marketing.
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Helps to produce and isolates samples for proteomics studies using cell culture techniques, immunoprecipitation, subcellular fractionation methods and protein sample preparation from tissues and/or biofluids.
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This is a senior-level position that requires a deep understanding of the financial markets, exceptional networking skills, and a strong background in commercial real estate development. Coordinate and manage regional & international travel arrangements for investor presentations with WS Development senior leadership.
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Desired Qualifications: B.S or M.S. Degree in Civil Engineering Licensed Professional Engineer (PE), or (EIT) 3+ years of demonstrated engineering design of Land Development Projects Utility Design Site Grading Storm Water Management Systems Zoning Research Permitting Research Proficiency with AutoCAD, Civil 3D software Salary and Benefits: Comprehensive Salary Package.
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Principal Scientist, Protein Production and Process Development. and with proteins expressed in mammalian cells with oversight of both upstream and downstream process development. The incumbent will interface with internal preclinical Immunology, Protein Modality, and DECODE platform teams, as well as the internal CMC Leader, to provide protein reagents and protein leads, including data packages supporting Development Candidate nomination.
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