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A minimum of 10 years of related pharmaceutical or biotechnology industry experience in clinical pharmacology, population PK, PK-PD modeling, DMPK, and/or pharmacometrics and a proven track record advancing programs through the drug development process, from discovery through IND to registration, informing data driven decisions on dose and schedule, making tough judgement calls where needed.
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Serve as the subject matter expert on cross-functional teams to lead projects, direct GLP bioanalytical validations and sample analysis across all nonclinical, DMPK and clinical pharmacology development.
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Global Discovery and Development Sciences (GDDS) Boston, part of the US R&D hub, is building a new siRNA Nonclinical Development department with cross-functional scientific expertise, including toxicology, safety pharmacology, PKPD, ADME, outsourcing management, and non-clinical project management.
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Act as the lead clinical pharmacologist on clinical pharmacology study teams to support clinical development: independently lead the design, protocol development, execution, analysis, and reporting of clinical pharmacology studies (e.g., food effect, BA/BE, human ADME, drug interactions, renal and hepatic impairment, etc.
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The Program Leader will lead a cross-functional team across clinical operations, regulatory affairs, clinical pharmacology, biomarkers, CMC, non-clinical, and medical to deliver against the program strategy.
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Support DMPK needs for clinical stage programs through close collaboration with Clinical Pharmacology and Toxicology. We are looking for a consummate teammate who seeks a scientifically rigorous and collaborative environment in which to grow their career in drug R&D. We are looking for an energetic and passionate Senior/Principal Scientist to join the DMPK team.
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Develop and implement an integrated medicinal chemistry strategy, working in concert with partners in Data Science, De Novo Discovery, Molecular and Cellular Biology, DMPK and Pharmacology to reach hit-to-lead and lead optimization goals.
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Potential IP areas include: biochemistry, biophysics, cellular/chemical biology, genomics, immunology, microbiology, molecular/systems biology, pharmacology, neuroscience, organic chemistry, synthetic biology, and biomedical/chemical engineering.
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Collaborate with high throughput biology, cell modeling, medicinal chemistry, and in vivo pharmacology to advance projects from hypothesis to IND-enabled programs. Collaborate with high throughput biology, cell modeling, medicinal chemistry, and in vivo pharmacology to advance projects from hypothesis to IND-enabled programs.
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Clinical Pharmacology and Pharmacometrics (CPP) provides characterization and prediction of the pharmacokinetics, pharmacodynamics and drug metabolism (PPDM) of the drug candidate in selected preclinical and all clinical areas, supporting drug discovery and medical therapeutics across many disease areas.
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Strong background in iPS cell and primary neuronal cultures, and in vivo experimental methods including pharmacology and efficacy readouts to support candidate nomination and characterization. A PhD degree with 10+ years or MS with 16+ years or BS with 17+ years’ experience in the field of Neuroscience, Neurodegeneration, Pharmacology or related discipline is required.
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You will work closely with colleagues across Development including autoimmune disease, Rare Disease and immuno-oncology, while also having a change to interact with colleagues in infectious disease. Executive Director, Program Leader, Rare Disease page is loaded.
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We can accomplish our mission by building deep expertise in large molecule end-to-end discovery such as Antibody discovery, protein engineering and optimization, molecular attribute characterization, target protein & expression sciences, and platform biology/in vitro pharmacology/assay development.
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You will partner with key stakeholders and colleagues in Clinical Pharmacology, Quantitative Systems Pharmacology, Statistics, Translational Modeling and Simulation, and other Research and Development lines to accelerate breakthrough cancer medicines that bring new hope to patients everywhere.
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Collaborate with a world class, multidisciplinary team of drug discovery scientists from medicinal and platform chemistry, DEL, in vitro pharmacology, biology, and data science to advance multiple small molecule programs as new clinical candidates for the treatment of several diseases.
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pharmacology job Title: principal consultant Company: Parexel in Lexington, MA
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