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Provide scientific/technical diligence and oversight on assay development activities for in vivo study sample analysis measuring gene therapy delivery, pharmacology, safety, and efficacy. Experience with molecular and cellular biology instruments and techniques, e.g., DNA/RNA/Protein purification, ddPCR and qPCR, flow cytometry, Western blotting, MSD, ELISAs, TapeStation, JESS.
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The Analytical Development Scientist I is an entry level position responsible for execution of sample analysis in support of the development of new pharmaceutical products. Perform sample analysis for in-process testing, release and stability testing for pre-commercial programs.
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Working within Fractyl's Gene Therapy Research Team, the Senior/Principal Scientist will be integral to the discovery and development of AAV-based gene therapies for the treatment and cure of diabetes, obesity, and other metabolic diseases.
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Provide oversight for DMPK/clinical pharmacology related sample management activities including management of BA CROs. Contribute to the design and oversight of toxicokinetic aspects for GLP toxicology studies.
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Ensures achievement of data management deliverables and milestones in coordination with cross functional team members including: Clinical Operations, Clinical Development, Biostatistics & Programming, Biomarker Operations & Sample Management, Clinical Pharmacology and Pharmacovigilance.
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B.A, B.S. in Biotechnology, Biology or Management, or related degree with 1+ years of sample management and/or sample logistics experience in a pharmaceutical, diagnostics or related research setting.
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Job Description: BioMedicine Design (BMD) High-Throughput Protein Production (HTP) Group is seeking a highly motivated scientist to support the molecular biology & protein production workflows: DNA construct design/assembly, PCR, sample preparation for sequencing, DNA production & quantitation, mammalian cell culture & transfections, protein purification & quantitation, and automated liquid handling.
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BioMedicine Design (BMD) High-Throughput Protein Production (HTP) Group is seeking a highly motivated scientist to support the molecular biology & protein production workflows: DNA construct design/assembly, PCR, sample preparation for sequencing, DNA production & quantitation, mammalian cell culture & transfections, protein purification & quantitation, and automated liquid handling.
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Sample preparation for sequencing. High throughput molecular biology operations, including PCR, ligation reactions (Gibson & ITA), & DNA purification using liquid handling automation. Bachelor's degree (0-2 years' experience) or Associate's degree (1-3 years' experience) with experience in Molecular Biology, Biochemistry, Biology, Biological Engineering or a related discipline along with a basic understanding of molecular biology and protein expression.
$30 - $33.8 an hourFull-timeExpandApply NowActive JobUpdated 7 days ago - UpvoteDownvoteShare Job
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Deep technical experience in multiple key technical aspects of immunoassay development; including but not limited to protein chemistry, antibody screening, antibody conjugation, assay diluent formulation; multiplexing; preanalytical sample processing; scale-up, assay optimization and troubleshooting; Real- Time PCR, immunoassays (immunoblotting and ELISAs), and gel-based assays (SDS-PAGE and CE-SDS); multivariate data analysis; analytical validation; clinical validation.
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Regular review of literature to maintain knowledge of scientific trends and industry processes, advance molecular biology and protein production methods. The candidate will be responsible for generating DNA constructs and performing high-throughput processes for macromolecule production (DNA, RNA, and protein.
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Customize and configure LIMS functionalities to streamline sample tracking, data integration, and reporting. Bachelor’s or Master’s degree in Computer Science, Bioinformatics, Computational Biology, or a related field.
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Ensure Biomarker Sample related collection, tracking, and storage in compliance with the Clinical Trial Protocol and Patient Informed Consent. Building of efficient biomarker sample logistics from study set-up until data delivery and study close-out.
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Author and execute study protocols governing bioanalytical studies to support in vivo studies and sample analysis. The functions of this Scientist position will include bioanalytical/analytical LC-MS sample analysis, LC-MS method development and validation, study design and execution, and data analysis with critical thinking.
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We are a market leader in automated bio sample management solutions and genomic services across areas such as drug development, clinical and advanced cell therapies for the industry's top pharmaceutical, biotech, academic and healthcare institutions globally.
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