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Preferred Experience and skills: Familiarity with molecular biology techniques, including PCR, restriction enzyme digestion, DNA purification, SDS-PAGE, western blot and microbial transformation (bacteria, yeast.
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Familiarity with molecular biology techniques, including PCR, restriction enzyme digestion, DNA purification, SDS-PAGE, western blot and microbial transformation (bacteria, yeast). The successful candidate will employ molecular biology and microbiology techniques to support all aspects of high-throughput molecular cloning including, DNA preparation, host transformation, host growth, protein expression, sample labeling, aliquoting, record keeping in our database and electronic notebook and other related tasks.
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Experiments include in vivo assays, flow cytometry, DNA/RNA/protein isolation and quantification including molecular biology techniques such as Gel Electrophoresis, qPCR, Western blot, and ELISA, tissue culture, microscopy, and various immunological assays.
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With a combination-focused pipeline that exploits the power of six scientific platforms (Immuno-Oncology, Tumor Drivers and Resistance, DNA Damage Response, Antibody-drug Conjugates, Cell Therapy, and Epigenetics) to help address unmet clinical needs in a host of cancers, we are motivated by a dedication to the scientific discovery and collaboration that will one day help eliminate cancer as a cause of death.
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DNA characterization and quality control testing using techniques such as gel electrophoresis, RNaseA testing, nanodrop, PCR, and preparation of samples for sequencing analysis (Sanger and NGS.
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Duties:Provide expert legal counsel and representation to clients in patent prosecution matters, focusing on biotechnology subjects such as antibodies, DNA or RNA therapeutics, chemical biology, and gene editing.
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Good understanding of cGMP, ICH, FDA, and USP guidelines is essential, including ICH guidelines on the control of impurities (organic, residual solvents, and elemental, DNA reactive (including ICH M7 option 4 / in silico control), and nitrosamines), and the ability to apply the guidelines in the context of the stage of pharmaceutical development.
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Conduct molecular biology assays such as DNA and RNA isolation, PCR and qPCR, western blot etc. The successful candidate will work with his/her supervisor to design, plan and conduct molecular biology and cell culture experiments to evaluate strategies to improve AAV production platforms through expression vector modification and/or host cell line engineering.
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Our DNA sequencing tools are used by tens of thousands of innovators, including Nobel prize-winners, dynamic biotech startups, research labs, and DIY biohackers. Who has familiarity with most common Sequencing, Synthetic Biology, cell and gene therapies, and molecular biology lab techniques.
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Basic wet lab skills, including but not limited to, molecular biology and biochemistry techniques such as DNA and RNA extraction, lysate preparation, qPCR, protein quantification, Western blot/WES/JESS, and ELISA is preferred.
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Other relevant experience includes multianalyte analysis from media or cell lysates (e.g. Luminex), ELISA, DNA and RNA isolation, PCR and RT-PCR, gene editing, various microarray technologies. Other relevant experience includes multianalyte analysis from media or cell lysates (e.g. Luminex), ELISA, DNA and RNA isolation, PCR and RT-PCR, gene editing, various microarray technologies.
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You have experience with cell line engineering and validation (e.g. stable retroviral transduction, transient DNA/mRNA transfection, CRISPR) Family planning support up to $45,000 (e.g., IVF/PGT, adoption, surrogacy, egg retrieval.
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We are working to develop novel DNA sequencing technologies for studying mutagenesis in model systems. Single-cell sequencing: New approaches allow us to dissect a tumor down to single cells and investigate the RNA expression or DNA mutations in each cell.
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Experience with state-of-the-art AI & ML methods applied to biological sequence data (DNA, protein)Hands-on experience with public omics, protein and immune repertoire datasets such as PDB, OAS, SAbDab. Strong experience with scientific programming languages (Python, R) and data science libraries.
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Laboratory work includes but is not limited to: processing and storing human specimens (blood, stool, urine, biopsies), PBMC isolation, serology analysis on BioFlash, EMA processing, RNA/DNA extraction methods, organoid biopsy care, etc.
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