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Contribute to the Biomedical Research drug discovery process by advancing the development and discovery of new in-vivo digital biomarkers. Explore and validate novel in-vivo digital biomarker hypotheses by leveraging expertise in physiology and behavioral neuroscience, combined with an understanding of human disease mechanisms.
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High level of technical expertise in some of these relevant areas: cell culture, protein/RNA/DNA analyses, in vivo animal studies (behavior, dosing, sample collection, stereotaxic surgery, etc.
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Alloy’s Translational Research team supports our drug discovery partners with in vitro and in vivo testing of therapeutic drug candidates across multiple modalities. This role will report to a Senior Scientist on the Translational Research team with autonomy owning various stakeholders, projects, and tasks in a dynamic start-up environment while keeping up the pace of Alloy.
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Experience with in vivo models of oncology or immune-related diseases is highly desired. Responsibilities will include: Independently design, plan and execute in vitro and ex vivo cell-based immunoassays to demonstrate proof of concept and generate mechanistic understanding of therapeutic candidates.
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Experience working with primary human tissue samples, and in vivo models of autoimmunity and inflammation is preferred. This position offers a unique opportunity to work in a dynamic and innovative environment developing your career at the interface of mechanistic research, drug discovery, and preclinical drug development.
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Oversee GLP and non-GLP in vivo (e.g. rodent and non-human primate) studies internally or out-sourced from lead selection screening through lead candidate IND-enabling work. Scientist/Senior Scientist - In Vivo Biology (Neuroscience.
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The ideal candidate will have neuroscience research experience employing a variety of in vitro/in vivo electrophysiology techniques including traditional whole-cell patch-clamp, extracellular field potential recordings, and qEEG. Additional computational or programming experience is also required.
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Performing in vivo catheterizations for measurement of vascular and chamber pressure in cardiovascular rodent models. Communicating, collaborating and consulting with veterinarians, peers and scientific investigators on best practice, optimization and production of in vivo, surgical models.
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Demonstrated technical proficiency in either whole cell patch clamp recordings in brain slices or LFP/single unit in vivo recordings of live animals. The candidate will implement in vivo/ex vivo electrophysiological and cellular assays to study circuit mechanisms of major psychiatric illnesses in the genetic models of psychiatric illnesses.
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You will purify proteins using standard purification techniques to deliver high quality reagents for use in in vitro assays or in vivo studies. Majoring in: Biology, Biochemistry, Biological/Biomedical Engineering, Pharmaceutical Sciences, or a related field.
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Experiments include in vivo assays, DNA/RNA/protein isolation and quantification including molecular biology techniques such as Gel Electrophoresis, qPCR, Western blot, and ELISA, tissue culture, microscopy, and various immunological assays.
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Position SummaryThis position is a key leadership role for the development of the In Vivo franchise at CRISPR. Reporting to the Senior Director of Regulatory Affairs CMC, you will work closely with cross-functional teams and partners to bring multiple novel therapies to patients.
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Manage development of in vitro and in vivo models to enable new target selection and characterization, and biomarker identification. Direct and execute scientific research and development in alignment with the strategies agreed upon by the senior Global Immunology leadership team and global project teams.
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Supporting scientists to optimize AAV capsids by targeted and/or random modifications based on capsid structural biology and library generation; developing molecular biology-based methods for library screening in vitro and in vivo.
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OVERALL RESPONSIBILITY The candidate will implement in vivo/ex vivo electrophysiological and cellular assays to study circuit mechanisms of major psychiatric illnesses in the genetic models of psychiatric illnesses.
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in vivo jobs Title: associate research Company: Biospace in Boston, MA
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