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Develop methods to quantitatively measure the purity and heterogeneity of AAV gene therapy vectors, including empty capsid, aggregation, and capsid protein purity. advancing our platform of gene therapy programs through clinical development, starting with lead programs in hemophilia and metabolic disorders of the liver, and building out a world-class product engine for adeno-associated virus (AAV) therapeutics.
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Perform UV, HPLC, SV-AUC and CE-based methods to quantitatively measure the purity of the AAV gene therapy vectors and support process development. Assess and implement new analytical platforms, such as DLS, SEC-MALS, etc., to determine AAV capsid identity, quality, and quantity.
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Working within Fractyl’s Gene Therapy Research Team, the Sci II / Senior Scientist will be integral to the discovery and development of next generation AAV-based gene therapies for the treatment and cure of diabetes, obesity, and other metabolic diseases.
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Experience with some or all of the following: cGMP manufacture and/or process development for CAR T, TCR, NK, cellular therapies, AAV, LV, RV. The incumbent will ultimately perform routine cGMP manufacture of multiple cell and gene therapy types/products at our state-of-the-art BaseCamp facility such as CAR-Ts, iPSCs, Adeno-Associated Virus (AVV) and Lentivirus (LV.
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The candidate will be a part of the Biologics Drug Product Development team in support of Gene Therapy programs in the Genomic Medicine Unit. The incumbent will have the opportunity to work on different facets of drug delivery and product development for modalities such as Lipid Nanoparticles (LNPs) and Adeno-associated virus (AAV.
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Many of our programs are derived from our TRACER™ AAV capsid discovery platform, which we have used to generate novel capsids and identify associated receptors to potentially enable high brain penetration with genetic medicines following intravenous dosing.
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Experience testing AAV, viral vectors, or other types of biologics. This position will play a key role in Alexion's Viral Vector Product Development analytical development team, interacting with internal teams within the Genomic Medicine and Product Development Clinical Supply groups.
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Some of our programs are wholly owned, and some are advancing with partners including Alexion, AstraZeneca Rare Disease;Novartis Pharma AG; Neurocrine Biosciences, Inc.; and Sangamo Therapeutics, Inc. For more information, visit www.
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The QC Analyst will support the gene therapy program pipeline including but not limited to routine GMP microbiological testing of AAV vector such as bioburden and endotoxin. The QC Analyst will support the gene therapy program pipeline including but not limited to routine GMP microbiological testing of AAV vector such as bioburden and endotoxin.
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The Research Associate will perform analytical chemistry and biophysical methods for the testing of AAV gene therapy products, to support process development and product characterizations. The Research Associate will perform analytical chemistry and biophysical methods for the testing of AAV gene therapy products, to support process development and product characterizations.
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BS or MS in Biophysics, Biochemistry, Analytical Chemistry or a related discipline with relevant lab experience. HPLC/UPLC experience analyzing nucleic acids, virus capsids, antibodies and/or other biologics materials by a variety of chromatographic methods (RP, SEC, IEX, SEC/FFF-MALS.
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Title: Research Associate I- Analytical Development. Investigate and evaluate cutting edge biophysical and analytical instrumentation. Status: Contract through the end of the year with the potential of full-time conversion.
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Experience with AAV gene therapy products, sterile injectables, and particle characterization is preferred. Knowledge and experience using biochemical or biophysical methods to characterize AAV-based viral vectors is desired but not required.
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Innova Solutions offers benefits( based on eligibility) that include the following: Medical & pharmacy coverage, Dental/vision insurance, 401(k), Health saving account (HSA) and Flexible spending account (FSA), Life Insurance, Pet Insurance, Short term and Long term Disability, Accident & Critical illness coverage, Pre-paid legal & ID theft protection, Sick time, and other types of paid leaves (as required by law), Employee Assistance Program (EAP.
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InnovaSolutions is immediately hiring for a QC Analyst. Benefits: InnovaSolutions offers benefits( based on eligibility) that include the following: Medical & pharmacy coverage, Dental/vision insurance, 401(k), Health saving account (HSA) and Flexible spending account (FSA), Life Insurance, Pet Insurance, Short term and Long term Disability, Accident & Critical illness coverage,Pre-paid legal & ID theft protection, Sick time, and other types of paid leaves (as required by law), Employee Assistance Program (EAP.
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aav job in Bedford, MA
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