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The role involves contributing to innovative approaches in evaluating the ADME of therapeutic proteins, peptides, and new modalities like RNbased therapeutics and antibody-drug-conjugates. It also includes evaluating the biotransformation of complex therapeutic proteins, such as antibody-drug conjugates, fusion proteins, multifunctional antibodies, and genetic medicines like siRNbased therapeutics.
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The drug product team is also investing in building new platforms to support complex formulations such as lipid nanoparticles, Antibody Drug Conjugates and AAV and other non-viral vector delivery.
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Working in IBRI’s Protein Therapeutics lab, the Staff Scientist will be involved in collaborative research projects that include preparation of recombinant proteins using diverse expression systems, use of these proteins as antigens to screen IBRI’s phage display recombinant human antibody library, and characterization of candidate antibodies for development as molecular diagnostics or as candidate therapeutics for use in translational studies.
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Our current groups include: Africa, Middle East, Central Asia Network, African American Network, Chinese Culture Network, Early Career Professionals, Japanese International Leadership Network (JILN), Lilly India Network, Organization of Latinos at Lilly, PRIDE (LGBTQ + Allies), Veterans Leadership Network, Women’s Network, Working and Living with Disabilities.
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This includes explanation of procedures, hazards and potential adverse events; explanation of immunization schedules, dose and antibody response; providing clear opportunity for donor to refuse participation; obtaining signature and date certifying informed consent.
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The Research Scientist, Antibody Discovery will be responsible for discovering therapeutic molecules to treat a variety of indications in our target species. As a member of Research and Breakthrough Innovation, the scientist will work collaboratively within a matrix environment to design and execute antibody discovery studies to elicit highly potent antibodies.
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