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They bring scientific talents in molecular biology, immunology, pharmacology, protein chemistry, computational biology, automation, genome engineering, software and other fields to make the future happen now.
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We are seeking a senior Clinical Scientist to support clinical research activities for our portfolio our immunology clinical programs, with a specific emphasis on severe immune-mediated diseases.
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Other responsibilities may include utilizing nonclinical PK and PK/PD data (including use of modeling and simulation techniques) to project optimal clinical dosing regimens, doses based on pharmacological/clinical targets, human starting doses, and biomarker exploratory data (including biochemical and molecular data from quantification of mRNA, multi-panel flow cytometry, and protein expression.
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You will be an integral member of a dynamic research team, collaborating with research scientists at multiple Amgen sites and working closely with groups in other functional areas, including protein science, in vivo pharmacology, and computational biology.
$55Full-timeExpandApply NowActive JobUpdated 3 months ago - UpvoteDownvoteShare Job
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Experience in Synthetic Biology, specifically in the design of transcriptional circuits and/or protein engineering, is preferred. The successful candidate will perform experimental work on protein engineering, primary human T cell culture, lentiviral transduction, and mouse tumor models.
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By leveraging our deep insights into oncology and immunology, advanced protein engineering/design technologies, and extensive knowledge in clinical development, our vision is to uncover the novel therapeutic targets and develop the best-in-class and first-in-class biotherapeutics for the patients with significant unmet medical needs.
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The Company is seeking to hire a Principal Scientist, Large molecule Pharmacokinetics expert to design and conduct PK/PD and biodistribution studies to support Discovery and Development of novel blood-brain-barrier penetrant transport vehicle (TV) biotherapeutics, including oligonucleotide transport vehicle conjugates.
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Driven by a collective of diverse experts across immunology, synthetic biology, molecular biology, automation and computational biology, we are united in purpose to deliver radical breakthroughs for people with cancer, and prioritize the team’s outcomes over individual goals to achieve our company mission – together.
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Strongest consideration will be given to candidates with expertise in molecular cloning, nucleic acid chemistry, in vitro transcription, mRNA analytics, protein expression analysis, and basic cell culture.
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Must have protein purification experience including chromatography separations and filtration operations. We strive to have a remarkable impact on people's lives across several key therapeutic areas - immunology, oncology, neuroscience, and eye care - and products and services in our Allergan Aesthetics portfolio.
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Scientist, Osteosarcoma Cell Therapy Initiative, UCSF Roybal Lab, Allen Lab SCHOOL OF MEDICINE – Microbiology and Immunology Description The mission of the UCSF Osteosarcoma Cell Therapy Initiative is to support the development of the next generation of cellular therapies to treat this disease.
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Proficient in LCMS peptide mapping for PTM analysis of antibodies, bispecifics, and similar protein therapeutics and mass spectrometry analysis of intact proteins. General understanding of CMC Analytical Development of protein therapeutics is desired.
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We are expanding our capabilities in informatics across multiple drug discovery platforms, including DNencoded library (DEL) screening, peptide-display discovery, support for RNbased therapeutics, parallel medicinal chemistry (PMC), targeted protein degradation, and high-throughput screening (HTS.
$131,000 - $225,400 a yearFull-timeExpandApply NowActive JobUpdated 5 days ago
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