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The Gene Therapy group uses a collaborative, interdisciplinary, and forward-thinking approach to solving many of the current challenges facing genetic medicine discovery and drug development.
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About Charles River Cell Solutions Charles River Cell Solutions is a global leader and trusted brand in the customization of human-derived biological products and services for biomedical research, drug discovery, and cell and gene therapy development.
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Contribute to the development of automated workflows to support assays such as immunoassay (IA), peptide stability, protein binding, automated sample preparation for plasma and tissue drug concentration analysis, cell culture maintenance & cell-based assays.
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As part of the Discovery Biotherapeutics efforts at BMS, the Principal Scientist will play a key role in advancing antibody drug conjugates technologies at BMS. The Discovery Biotherapeutics team at BMS seeks to understand the structure and function of complex molecules such as bispecific antibodies, antibody drug conjugates and endogenous proteins in order to optimize their utility as therapeutic agents.
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You will implement machine learning and computational chemistry-based methods to elucidate novel mechanisms of action for small molecule drug discovery. At Genentech Computational Sciences (gCS) Prescient Design, we are seeking a highly motivated Machine Learning Scientist to help drive research on Machine Learning for Drug Discovery.
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Responsibilities:We are currently seeking a Director, Drug Metabolism and Pharmacokinetics, who will have scientific oversight of one or more of the small molecule discovery projects and will manage the in vitro and in vivo PK, ADME and bioanalytical assays.
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Job Title - Contract Scientist, Protein Chemistry, Large Molecule Discovery. Large Molecule Discovery team is looking for a Contractor- protein chemistry and enzyme assay to support our growing biologics portfolio.
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Working knowledge of NGS methods used in research, with experience using liquid handling and automation being preferable (HTS, Assay Development, or molecular or structural biology backgrounds will also be considered) Experience with workflow optimization in genomics, drug discovery, and structural biology.
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Deep understanding of cancer immunology, oncogenic signaling pathways (RAS, PI3K), and translational drug development, as evidenced by first-author publications, patents, and past success in R&D.
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Our team has created the industry's most advanced molecular AI platform called GEMS (Genesis Exploration of Molecular Space), to accelerate and optimize small molecule drug discovery and to enable the discovery of novel first-in-class and best-in-class small molecule drugs for challenging and/or undruggable targets.
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Quantitative Systems Pharmacology (QSP) & Physiologically Based Pharmacokinetics (PBPK) have become important components of discovery and clinical development. + Assist therapeutic area expert modelers to accelerate efforts and ensure timely model development and calibration to impact drug development programs and coordinate technology development.
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Collaborate to identify, evaluate, and recommend novel and cutting-edge automation and assay strategies to drive our discovery programs, including machine learning and artificial intelligence. The Scientist will work collaboratively with other team members in a fast-paced environment to operate automated laboratory equipment and systems to support various DMPK assays.
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Our client is an innovative Oncology biotechnology company developing next-generation targeted radiation therapies - one of the most talked about areas of drug development. Create technology transfer package for CDMO’s by translating pre-clinical analytical methods and drug product synthesis to processes suitable for clinical development.
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Responsibilities -Develop assays for GMP release of gene therapy products-Develop assays for product characterization of gene therapy products-Develop assays for AAV/protein/DNA to assist in evaluation of process change, formulation andstability study-Report project status (development plans, timelines, and results) to supervisor and technical teams.
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Experience or training in clinical pharmacy, medicine, Pharmacometrics, pharmacology, or drug development. The Drug Research Unit led by Drs. Deitchman and Huang are seeking an Assistant Specialist ideally with Master's training in Biostatistics, a background in pharmacy, pharmacology, and/or pharmacometrics to perform clinical and translational PK/PD and/or biomarker studies relevant to research programs based in the DRU (i.e., HIV, HIV cure, malaria, PKPD in pregnant women and pediatrics) and with collaborators.
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drug development discovery jobs Title: engagement in South San Francisco, CA
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