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Hands-on experience in tissue culture and cell-based assay (general tissue culture, cell banking, cell proliferation, electroporation, transfection, transduction, flow cytometry, AAV, and ELISA.
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The group performs pharmacokinetic (PK) evaluations, pharmacodynamic (PD) biomarker measurements, immunogenicity risk assessments, and exploratory clinical research during AAV product development.
$93Full-timeExpandApply NowActive JobUpdated Today - UpvoteDownvoteShare Job
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The Siren team is the power fueling our bold idea to create the world's first universal AAV immuno-gene therapy for cancer, and we're growing our team! Leverage NGS and machine learning techniques together with the sequencing and data science teams to improve the development of tailored AAV capsids.
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Develop and lead CMC Regulatory strategies for a portfolio of programs in development, including AAV gene therapies and small molecule drugs. At least two or more years of Regulatory CMC experience with AAV Gene Therapy programs is required.
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Lead analytical development and quality control for AAV gene therapy, small molecules, antisense oligonucleotides, mRNA and protein therapeutics. Modalities include AAV gene therapy, small molecules, antisense oligonucleotides, mRNA and protein therapeutics.
$289,850 - $392,150ExpandApply NowActive JobUpdated Today - UpvoteDownvoteShare Job
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Proven expertise in downstream process development for viral vectors, with a focus on AAV and lentiviral vectors. Responsibilities Design, optimize, and scale-up downstream processes for the purification of viral vectors, with a focus on AAV and lentiviral vectors.
$115,000 - $150,000 a yearFull-timeExpandApply NowActive JobUpdated Today - UpvoteDownvoteShare Job
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Experience with high throughput molecular cloning techniques, AAV transductions and CRISPR is advantageous. Experience with CRISPR-Cas gene editing systems and AAV transductions desired.
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As part of the screening projects, they will be responsible for cloning and producing high quality plasmids for AAV production, and the in vitro testing of AAV vectors in a variety of target cell lines.
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We seek to unlock the full potential of gene therapy using our platform, Therapeutic Vector Evolution (TVE), which combines the power of directed evolution with our approximately one billion synthetic AAV capsid-derived sequences to invent evolved vectors for use in our products.
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The current role is for a Research Associate I/II, AAV Engineering to join our team and advance our platform, designing and building new systems to deliver CRISPR in vivo. Work closely with AAV engineering leads to creatively design, rapidly build, and efficiently screen AAV vectors for the controllable delivery of genome editing tools to target human cells and tissues.
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Hands-on expertise in tissue culture and cell-based assays (including general tissue culture, cell banking, cell proliferation, electroporation, transfection, transduction, flow cytometry, AAV, and ELISA.
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Working experiences with lentivirus or AAV production and application, CRISPR technology for genome editing are highly desirable. R&D Partners is seeking to hire aResearch Associate II in South San Francisco, CA.Your main responsibilities as a Research Associate II:Provide viral vector core services, which include lentiviral library production, Adeno-associated virus (AAV) production and viral vector analytics.
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In addition to TVE, our technology includes a robust AAV manufacturing platform and onsite manufacturing facility that allows us to rapidly produce and test research grade material and scale up to GMP clinical material.
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Experience using viral (lentiviral, retroviral or AAV) and/or non-viral gene delivery methods (e.g., CRISPR mediated knock-in or targeted genome integration) highly preferred. The candidate's main responsibilities will include: a) novel assay development, b) in-vitro T cell circuit design and validation, c) establishment of in-vivo tumor models, d) compiling pre-clinical results to support the designation of clinical vector design, and e) leading the in-vitro and in-vivo pharmacology characterization of therapeutic product candidates in collaboration with a process development team towards an IND filling.
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The Sr. Research Associate will support the Discovery Bioscience team and assist in developing and executing screening assays for the evaluation of AAV vector products. Execute cell-based assays to test AAV vector candidates using routine procedures (AAV transduction, transfection, titer measurements, and cell differentiation.
$86,300 - $115,000 a yearFull-timeExpandApply NowActive JobUpdated 1 month ago
aav job in Emeryville, CA
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