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Investigate and validate mechanism of action of drug leads by conducting in vivo, ex vivo and in vitro pharmacology experiments. The position may also involve in ex vivo and in vitro pharmacology experiments.
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Effective cross-functional collaboration, especially with Institutes of Science, In Vivo Pharmacology and DMPK, in the optimization of drug leads and candidates. Strong knowledge and agility in study design and data interpretation and in the integration of Toxicology studies in the drug progression paradigm, as well as in the incorporation of safety endpoints in pharmacology studies.
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Extensive hands-on experience building quantitative in vitro assays (biochemical and cellular) and expertise with in vivo pharmacology models in an oncology drug discovery setting. Lead and collaborate with project teams to develop in vitro pharmacology strategies and support Atomwise preclinical oncology programs.
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Responsibilities:We are currently seeking a Director, Drug Metabolism and Pharmacokinetics, who will have scientific oversight of one or more of the small molecule discovery projects and will manage the in vitro and in vivo PK, ADME and bioanalytical assays.
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PhD in life science-related fields (Immunology, Molecular Biology, Pharmacology, Chemistry, and Biochemistry) or Master's with 6+ years in science-related fields. Conduct literature search to design in vitro/in vivo models and conduct thorough research to initiate pipeline development.
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Responsibilities will include assisting in the in vitro characterization of the pharmacology of the radiopharmaceuticals by performing techniques like tissue culture, protein expression and purification, immunoblot, flow cytometry, biolayer interferometry, qPCR. Moreover, this role will require direct animal handling, which will include establishing and maintaining an animal colony of mouse models of human cancer, and small animal imaging and treatment studies.
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The Associate Scientist III/Scientist I, Neuroscience will partner with scientific and project teammates to develop and execute mid/high throughput biochemical/cellular assays, in vitro mechanistic experimentation, and explore novel models to advance early targets through our pipeline.
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Participate in multidisciplinary teams including Biology (in vitro and in vivo pharmacology), and Chemistry (production, analytical sciences, and platform chemistry groups) - Present results through team meetings and recommendations to management.
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We are currently seeking a Director, Drug Metabolism and Pharmacokinetics, who will have scientific oversight of one or more of the small molecule discovery projects and will manage the in vitro and in vivo PK, ADME and bioanalytical assays.
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It is one of the market leaders in certain testing and laboratory services for genomics, discovery pharmacology, forensics, advanced material sciences and in the support of clinical studies, as well as having an emerging global presence in Contract Development and Manufacturing Organizations.
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It also has a rapidly developing presence in highly specialized and molecular clinical diagnostic testing and in-vitro diagnostic products. Degree in an applicable science (biology, chemistry, pharmacology.
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In this position, you will assist with the design and execution of in vivo pharmacology experiments in rodents. BSc, MSc in pharmacology, biology or related field with 1-5 years of post-graduate relevant experience.
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Degree in Immunology, Bioengineering, Molecular Biology, Cell Biology, Pharmacology, Biochemistry or related field. Contributing to the design, implementation, and interpretation of in vivo and in vitro experimental studies.
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As a Director of In Vitro Pharmacology in the Institute of Medicine (IOM) at Altos Labs, you will join a dynamic team in a unique environment where leading research labs work side by side with industry scientists.
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Ph. D. (or equivalent industry experience) in analytical chemistry, pharmacokinetics, pharmacology, biochemistry, with 2+ years of experience, or relevant technical field experience. Establish in vitro ADME assays (metabolic, stability, drug permeability, and protein binding) to support multiple discovery programs.
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vitro pharmacology jobs in Alameda, CA
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