Principal Programmer, Statistical Programming (Remote)

Overview As Principal Statistical Programmer you lead advanced SAS-based clinical programming efforts, ensuring accurate, timely analyses and compliant submissions. You collaborate with statisticians, data management, and other stakeholders to drive study tasks and eCTD submissions. You provide expert technical guidance, maintain regulatory compliance, and shape data analysis workflows. This role combines leadership, technical prowess, and cross-functional influence to support Vertex’s clinical programs and submissions. Compensation / Benefitsmedical, dental and vision benefitsgenerous paid time offeducational assistance programsstudent loan repaymentcommuting subsidy401(k) matching Responsibilitieslead SAS-based programming and QC of code and outputssolve complex clinical trial reporting problems and support daily operationscollaborate with statisticians, data management, and other departments on data and submission activitiescreate all files and analyses required for eCTD submissions (ISS/ISE)provide leadership to ensure compliance with Vertex SOPs and FDA/ICH/GCPmanage documentation to support data analysis, reporting, and CDISC data submissionparticipate in cross-functional teams on SOPs, process improvements, system validation, and tool integration Key requirementsexpert-level SAS language, procedures, and functions (Macro, BASE SAS, SAS/STAT, SAS/GRAPH)intermediate knowledge of CDISC standardsclinical trial regulatory submission experienceeffective written and verbal communicationstrong communicationleadership and project managementcross-functional collaborationSAS programmingSAS Macro languageSAS/STAT