General Manager, Direct-to-Patient

General Manager, Direct-to-PatientExtension Health / EHRX — New York City (In Person) | Full-Time  OTE $180K - $230KAbout Extension Health & EHRXExtension Health is NYC's premier longevity medical center, an all-under-one-roof platform for personalized healthspan optimization, offering the most advanced diagnostics and advanced therapeutics available today. Founded by Dr. Jonathann Kuo, MD, our physician-driven team has helped 50,000+ patients take control of their health and longevity across our West Village and Midtown flagship locations.EHRX is our fast-growing telehealth brand, bringing compounded prescription peptide therapy directly to patients nationwide. LegitScript Certified, 503A pharmacy-backed, and physician-led, EHRX is building a rigorous, accessible model for direct-to-patient care.We're building something rare: a clinically credible brand with serious digital infrastructure. This is a significant leadership opportunity to own the direct-to-patient business across both brands.The RoleWe're looking for a commercially driven General Manager to own and grow our direct-to-patient business across Extension Health and EHRX. This is a true GM role. You'll hold full P&L responsibility, set the revenue strategy, and build the team and systems needed to scale.You are not a functional specialist. You're a builder and an operator who knows how to drive revenue, move fast, and make smart decisions with imperfect information. You understand that the best direct-to-patient health businesses win on trust, product, and conversion, and you know how to optimize all three.This role reports directly to the CMO / VP of Revenue/Growth and works closely with the clinical and marketing teams.What You'll OwnFull P&L responsibility for direct-to-patient revenue across Extension Health and EHRX, with clear quarterly and annual targetsRevenue strategy and execution, from traffic acquisition and conversion rate optimization to retention, LTV, and subscription growthEHRX growth, scaling the telehealth business nationally, including channel strategy, patient acquisition, funnel optimization, and new treatment launchesExtension Health online pharmacy, optimizing our online pharmacy for patients and membersGo-to-market leadership, owning product launches, promotional calendars, and pricing strategy for EHRXPaid media and performance marketing, either managing directly or overseeing an agency/internal team across Meta, Google, and emerging channelsTechnology and operations, owning the direct-to-patient stack, conversion funnel, and telehealth patient journey from first click to first shipmentTeam building, hiring and developing a high-performance team as the business scalesReporting and accountability, weekly revenue reporting, forecasting, and clear-eyed analysis of what's working and what isn'tWhat We're Looking For6-10 years of experience in DTC, digital health, or direct-to-patient businesses, with at least 2-3 years in a senior leadership or GM-level roleA track record of hitting revenue targets and growing an online business, not just managing oneExperience with DTC performance marketing. You understand CAC, LTV, payback periods, and how to build a profitable acquisition engineFamiliarity with telehealth, healthcare ecommerce, or regulated consumer health products is a strong plusOperator mentality. You build systems, hold people accountable, and stay close to the numbersComfortable in a founder-led, fast-moving environment where the strategy evolves and execution has to keep paceStrong commercial instincts. You think about margin, pricing, and unit economics, not just top-line growthExcellent communicator and cross-functional collaborator. You'll work closely with the clinical, marketing, and operations teamsNice to HaveExperience scaling a subscription or membership-based health or wellness businessFamiliarity with Shopify, telehealth platforms (e.g., Qualiphy), or compounding pharmacy workflowsBackground in peptide therapy, regenerative medicine, or longevity/wellness categoriesKnowledge of FDA/FTC compliance considerations in digital health marketingExperience managing or working alongside a licensed clinical teamWhat We OfferCompetitive base salary commensurate with experience, plus performance bonus tied to revenue goals — in compliance with NYC salary transparency requirements, a specific range will be provided to all candidates who advance to the screening stageTrue ownership of a high-growth P&L with the backing of an established, physician-led brandA seat at the leadership table of one of the most exciting health and longevity companies in the countryThe chance to build a national direct-to-patient business on top of a clinically credible, trusted foundationA collaborative, mission-driven team environmentTo Apply: Send your resume and a brief note on why you're the right person to lead this business to