Scientist - Antibody function and mammalian synthetic biology

Nabla Bio is building AI to design new medicines. We combine cutting-edge ML with fast, human-relevant lab validation to create biomolecules on demand. This lets us go after hard diseases and build new drug formats that traditional approaches can’t reach. We’re backed by top investors like Radical and Khosla Ventures and have forged significant partnerships with leading pharma companies.The roleFueled by partnerships and increasing demand for internal R&D, we will be looking to you to develop and perform high-throughput and multiplex cell-based assays for evaluating antibody function. This will include:Engineering transient and stable cell lines with diverse reporters in both model and disease systemsCollecting and analyzing quantitative measurements using flow cytometry, immunoassays, -omics (pooled, single cell), and other techniques.Prioritizing top development candidates by functional and binding characterizationWorking together with our dry-lab and other wet-lab scientists to establish a rapid and seamless testing pipeline for characterizing machine learning generated antibody designsQualificationsPhD-level knowledge and experience in mammalian synthetic biology and cellular assay developmentExtensive experience in molecular biology: plasmid design, single-insert cloning, library cloning, bacterial transformation and culturing.Extensive experience in cell line engineering and tissue culture. Includes experience with transient and stable transfections, lentiviral transduction, electroporation; and, experience troubleshooting biological readouts. Experience culturing a wide variety of immortalized and primary disease cells is a plus.Well-organized, and would enjoy establishing an operationally efficient engineering and characterization pipeline that works reliablyProblem-focused, and interested in working in a high-intensity, fast-paced environment often driven by deadlinesValue unblocking colleagues before yourself, and are excited to mentor/train junior colleaguesWhat We OfferA fast-moving environment where you can build and ship tools that impact real drug programsA small, focused team where your scientific and engineering decisions have outsized impactHighly competitive salary, equity, and benefits package