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Alloy’s Translational Research team supports our drug discovery partners with in vitro and in vivo testing of therapeutic drug candidates across multiple modalities. You have experience with primary human immune cell activation assays using multparameter flow cytometry.
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Expertise in primary human cell culture, multi-color flow cytometry, multiplex cytokine detection, functional immune cell assays (proliferation, cytotoxicity, chemotaxis) and assay development is essential.
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More information can be found at Description:The Senior Research Associate, Discovery will work with Tr1X's Research and Development team to design and execute in vitro and in vivo studies to characterize candidate cellular therapy products to support pipeline program advancement.
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Overview Axle is seeking a highly ambitious, adaptable, structured, and detail-oriented Flow Cytometry Immunology Scientist to join our vibrant team at the National Institutes of Health (NIH), National Institute of Allergy and Infectious Diseases (NIAID), Vaccine Research Center (VRC), Vaccine Production Program (VPP.
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Develop and enhance complex in vitro and ex vivo research and development capabilities. Proficiency with cell-based assays, ELISA, MSD, qPCR, RNseq, microscopy, histology/pathology (e.g., IF/IHC/ISH), and/or flow cytometry.
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Performing ex-vivo immunophenotyping using multicolor flow cytometer and analyzing flow cytometry data. A general knowledge of immunology and immune-oncology field a well experience in tissue culture and cell-based assays and flow cytometry is a plus.
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Essential Qualifications: PhD and independent research or development experience using flow cytometry methods. Senior Scientist, Flow Cytometry~ onsite role in Rockville, MD~ You will serve as the Flow Cytometry Subject Matter Expert (SME), driving innovation in research initiatives.
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Multi-color flow cytometry and bulk and single cell sorting, using FACS and MACS-based methods. Key Responsibilities: Offer flow cytometry expertise and provide technical support.
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Execution and analysis of multiple flow cytometry-based assays for characterization of Pan-T, cell therapy products and in-vivo tissue samples. The primary responsibilities will involve the isolation of primary lymphocytes for pre-clinical research, CAR-T cell production, characterization of various products using flow cytometry and other in-vitro assays, along with scheduling and management of several direct reports.
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Develop and validate immunological assays (, flow cytometry, ELISA, CyTOF, cytokine profiling) to evaluate drug candidates' efficacy and mechanism of action. Oversee in vivo and in vitro studies, including development and optimization of disease models, study design, data collection, and interpretation.
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Expertise in a relevant platform technology (immunohistochemistry, digital pathology, flow cytometry, or genetics), including assay development, data analysis, and clinical application, is required.
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Experience in utilizing platforms including IncuCyte, JESS, Flow based cell sorter, ELISA, and MSD in the context of oncology-based drug discovery is a plus. " Experience in utilizing platforms including IncuCyte, JESS, Flow based cell sorter, ELISA, and MSD in the context of oncology-based drug discovery is a plus.
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Expertise in Flow Cytometry, FACS cell sorters, FlowJo, PCR etc. Skilled in Assay Development, Cell isolation, Cell engineering, Gene editing (CRISPR, Lentiviral, Retroviral) Design and run in vitro and in vivo validation assays of TCR targets.
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This role of Senior Research Associate for the Analytical Development (AD) position will be responsible for the execution of routine testing, including but not limited to flow cytometry assays used to characterize or release engineered CAR-T cell drug products.
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The candidate is expected to have a firm grasp of human T cell biology and the design and analysis of complex multicolor flow cytometry endpoints. Deep understanding of flow cytometry and immunophenotyping with complex flow panels.
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vivo flow cytometry research associate drug development jobs
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