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Designing, coordinating, executing, and analyzing in vitro and in vivo experiments. Developing in vitro functional assays for the characterization of allogeneic cell therapy candidates. Experience in planning and executing in vitro functional assays to characterize primary immune cells including, but not limited to, cytotoxicity assays, cytokine/chemokine measurements, phenotypic characterization, and proliferation assessment.
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The Screening Bioassay and Automation team is focused on in vitro cell-based assay with a unique expertise in high-throughput biology and laboratory automation. Develop advanced in vitro cell-based assays for characterization of mRNA vaccine bioactivity to support a wide range of preclinical studies.
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This position will be responsible for designing, performing, and interpreting in vitro and in vivo studies for drug discovery programs. Design, execute, and interpret cell-based in vitro experiments to explore the therapeutic potential of small and large molecules.
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Contribute to the project development as well as perform cellular immunological techniques, including multi-color flow cytometry, ELISA, MSD and in vitro immune cell assays. The Amgen Translational Immunology and Safety Sciences group based in South San Francisco, CA, is seeking a Principal Scientist to independently investigate immune related safety assessment with in vitro approaches and provide immuno-toxicological evaluation strategy to support Inflammation pipeline projects.
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Organize and document all experimental data and connect with all related in vitro and in vivo IND-enabling studies. Coordinate the design of in vitro and in vivo studies for clinical candidates.
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This position is responsible for performing basic clinical laboratory techniques in the IVF Laboratory involving in vitro fertilization, gamete handling, insemination and laboratory quality control.
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Reporting to the Nuclear Medicine Supervisor, incumbent is responsible for the performance of the full range of in vivo and in vitro Nuclear Medicine procedures utilizing radiopharmaceuticals and related chemical substances.
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Participates in research in the study of calcium signaling (in-vivo and in-vitro) in retinal synapses during development, adulthood, and disease. Knowledge of confocal microscopy, immunohistochemistry, molecular biology assays, and zebrafish handling is preferred.
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We use a variety of in vivo and in vitro approaches to investigate a novel pathogenic link between VEGF-A and NLRP3 inflammasome activation. In summary, our laboratory uses a large number of diverse experimental approaches (human genetics, mouse genetics, chemical screens, in vitro assays, cutting-edge imaging technology) to define novel mechanisms in angiogenesis, wound healing and inflammation.
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QuidelOrtho unites the strengths of Quidel Corporation and Ortho Clinical Diagnostics, creating a world-leading in vitro diagnostics company with award-winning expertise in immunoassay and molecular testing, clinical chemistry and transfusion medicine.
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You will also work with the internal drug development team as well as collaborators to deploy Manifold's proprietary protein barcoding technology for in vitro and in vivo drug development efforts.
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Perform a full range of nuclear medicine diagnostic imaging, non-imaging, In-vitro and therapeutic procedures, including highly specialized computer assisted studies such as gated, tomographic, dual-modality (SPECT/CT and PET/CT), and quantitative procedures.
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Ensure selection of appropriate in vitro and or in vivo methods and animal models to evaluate absorption, distribution, metabolism, excretion (ADME), and pharmacokinetic (PK) of radio-Theranostics drugs in GLP settings.
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The Sr. Scientist is expected to divide time between working in the lab and at the desk and providing training and guidance to junior team members in their creation of design transfer documentation and execution of NGS experiments to support in vitro diagnostic (IVD) design transfer.
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Cell biology techniques: Mammalian cell culture, in vitro cellular assays (cell viability assay, proliferation, invasion, apoptosis), luciferase assay. Molecular biology techniques: DNA/RNA extraction, gene expression analysis (PCR/RT-PCR), western blotting, ELISA, Next Generation Sequencing, flow cytometry.
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