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Based on our innovative approach to developing genetic medicines, as well as our industry-leading internal manufacturing capability and expertise, we have become the Astellas Center of Excellence for their newly created Genetic Regulation Focus Area. We are currently exploring three gene therapy modalities: gene replacement, exon skipping gene therapy, and vectorized RNA knockdown, with plans to expand our focus and geographic reach under Astellas.
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Adverum is a clinical-stage gene therapy company targeting unmet medical needs in ophthalmology and rare diseases. Adverum develops gene therapy product candidates designed to provide durable efficacy by inducing sustained expression of a therapeutic protein.
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Significant experience with analytical development, method fit for purpose assessments including validation, and assay troubleshooting in advanced therapy medicines (lenti-viral vector, gene therapies, and ex-vivo cell therapies.
$170,000 - $205,000 a yearFull-timeExpandApply NowActive JobUpdated 10 days ago - UpvoteDownvoteShare Job
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The Research Specialist C provides support for multiple research projects related to improving gene/cell therapy. Primary duties include molecular biology work such as RNA and DNA extraction, plasmid preparations, and lentiviral/retroviral vector work.
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We seek to unlock the full potential of gene therapy using our platform, Therapeutic Vector Evolution (TVE), which combines the power of directed evolution with our approximately one billion synthetic AAV capsid-derived sequences to invent evolved vectors for use in our products.
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The individual will focus and work along a group of scientists to develop small- and large-scale lentiviral vector (LVV) gene therapy vectors across various preclinical programs and disease areas.
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Minimum of 10+ years working in a Quality, Engineering, or Manufacturing role (or combination thereof) within a commercial biopharmaceutical, cellular therapy, or gene therapy organization.
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Key Words: Analytical Development | Method Development | Assay Development | MDV | Protein Characterisation | Product Characterisation | Protein Analysis | AAV | Viral Vector | Gene Therapy | GMP | QC | Quality Control | CMC | Biologics | Biopharmaceutical | C> | ATMP.
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We are inviting applications for postdoctoral positions to pursue multiple research topics that encompass: gene therapy using AAV vectors, RNA therapy, gene editing, immunology, virology, and AAV vector development.
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GenScript ProBio is the subsidiary of GenScript Biotech Corporation, proactively providing end-to-end CDMO service from drug discovery to commercialization with proactive strategies, professional solutions and efficient processes in cell and gene therapy (CGT), vaccine, biologics discovery and antibody protein drug to accelerate drug development for customers.
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GenScript's businesses encompass four major categories based on its leading gene synthesis technology, including operation as a Life Science CRO, enzyme and synthetic biology products, biologics development and manufacturing, and cell therapy.
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GenScript ProBio's total cell and gene therapy solution covers CMC of plasmid and virus for IND filing as well as clinical manufacturing and commercial manufacturing. In terms of viral vector service, GenScript ProBio has a stable and high-yield viral vector platform.
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Or more years industry experience in Laboratory Operations or related function in clinical / commercial biologics, cellular therapy, or gene therapy biotech companies. Work closely with Global Product Quality, External Manufacturing, and Supply Chain to understand forecasts and deadlines to ensure timely CoA/CoT (Certificate of Analysis/Certificate of Testing) generation for Cell Therapy vector products.
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Champion the advancement of the AAV viral vector production and purification platform through creative solutions including technology scouting and DoE experiments to accelerate gene therapy programs.
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Minimum of 5 years in a client-facing sales role in the life sciences industry, with preferred experience in the biopharma industry selling into the cell and gene therapy client segments, with proven track record of being a top performer.
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