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Cell culture, RNA biochemistry, protein purification, preparation of libraries for high-throughput sequencing, and other duties as assigned. Experience working with RNA, protein purification, bioinformatics and/or mouse work would be a plus.
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Experience in therapeutic drug discovery, gene therapy, or RNA therapeutics. Hands-on experience with cell-based assays and general molecular biology methods including, but not limited to, cell transfection, IVT, RNA extraction, qPCR, ddPCR, FACS, TapeStation, or Fragment Analyzer.
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They will be responsible for in vitro transcription (IVT) optimization, purification, and cell-based characterization of new RNA designs across various cell models. Hands-on experience with cell-based assays and general molecular biology methods including, but not limited to, cell transfection, IVT, RNA extraction, qPCR, FACS.
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Work closely with RNA production, LNP/RNP formulation, and in vitro and in vivo team members. Characterize the RNA/RNP encapsulated LNPs for their size, zeta potential, morphology, encapsulation efficiency, integrity, and stability using relevant assays (DLS, TEM, Ribogreen, CE, AGE, PAGE, UV-VIS, HPLC, etc.
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Avidity Biosciences, Inc.'s mission is to profoundly improve people's lives by delivering a new class of RNA therapeutics - Antibody Oligonucleotide Conjugates (AOCs). Avidity is revolutionizing the field of RNA with its proprietary AOCs, which are designed to combine the specificity of monoclonal antibodies with the precision of oligonucleotide therapies to address targets and diseases previously unreachable with existing RNA therapies.
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O RNA and protein biochemistry, such as purifying proteins, synthesizing RNAs, performing fluorescence assays, running gels and western blots. The Walker lab has recently identified posttranslational modifications regulating activity of eIF4A, the DEAD-box RNA helicase required for mRNA association with ribosomes in all eukaryotic cells, and linked these events to regulation of translation and RNA granule levels in yeast.
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We are looking for candidates as Research Associate I or II, Oligonucleotide Chemistry to join our discovery chemistry team to advance cutting-edge RNA editing drug discovery programs. Previous experience with RNA/Oligonucleotide therapeutics is preferred but not essential.
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You can learn more about us by visiting DescriptionWe are looking for a CTO/CSO, RNA Delivery System (LNP) with a proven track record in biochemical engineering and nanomedicine to lead the development of novel delivery systems for different technology platforms, including mRNA vaccines, therapeutics, siRNA, and in vivo gene editing.
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ADARx has developed proprietary RNA targeting platforms and technology for silencing or editing target mRNA. ADARx has a growing pipeline of RNA targeting therapeutics for treating diseases across a range of therapeutic areas including genetic, cardiometabolic, complement-mediated diseases and central nervous system.
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Perform experiments involving PCR, Quantitative PCR, Western Blots, PCR Arrays, RNA and DNA extraction, protein expression, and purification. The incumbent will perform experiments involving PCR, Real-time PCR, Northern and Western Blots, PCR Arrays, RNA and DNA extraction, protein expression, and purification.
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In addition, review and approve CTL assay development and validation reports, relevant sections of clinical documents pertaining to AAV and RNA analytical testing and documentation for submission to regulatory agencies.
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Conducting timed pregnancy (occasional), DNA/RNA purification, and PCR-based genotyping while maintaining well organized and rigorous records. Duties include breeding colonies, DNA/RNA purification, and PCR-based genotyping while maintaining well-organized and rigorous records.
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Develop RNA purification, characterization, and analytical methods to generate therapeutic grade material for in vitro and in vivo studies. Strong RNA biology knowledge including genetic element (UTRs, codon, structure, IRES) optimization for enhanced protein translation.
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The RNA Therapeutics Institute faculty are recognized as scientific trailblazers, and include a Nobel Laureate, a Gairdner Prize recipient, the 2018 RNA Society early and mid-career award recipients, two National Academy of Sciences members, a Fellow of the National Academy of Inventors, and three Howard Hughes Medical Institute Investigators.
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The ideal candidate will plan and execute production and purification of novel RNA molecules, while demonstrating agility to learn new tools and techniques to characterize purity of the RNA molecules.
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rna job
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