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Manufacturing cGMP production activities include solution preparation, master/working cell bank production, upstream cell culture, downstream protein purification, mRNA and molecular therapeutics production, and small-scale fill/finish.
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Knowledge and experience with large scale protein purification, nucleic acid purification, and other chromatography application processes. Hands on experience with downstream analysis techniques including, but not limited to, HPLC, SDS-PAGE, Western Blots, ELISA, and ddPCR. Excellent verbal and written communication skills, logical and analytical thinking, ability to multitask.
ExpandApply NowActive JobUpdated 4 days ago - UpvoteDownvoteShare Job
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Good understanding and knowledge of the Biopharmaceutical /Biotech Industry and strong, working knowledge of chromatography plus hands-on experience in protein purification. Do you have a passion for protein purification and Bioprocess.
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We are looking for a Chromatography Sales Specialist to work with our expert Downstream BioProcess Specialist team supporting all relevant call points related to chromatography and resins. Support customer process development, purification, and manufacturing projects by providing product and application information, answering inquiries, giving presentations, assisting with logistics, and providing limited lab bench work in support.
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Must have experience in downstream purification process development and with techniques such as chromatography, ultrafiltration/diafiltration, membrane technologies etc. Have a strong fundamental understanding of various protein purification and technology transfer principles.
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Purification of biotherapeutics (antibodies, proteins, viral vectors, ADCs) This position is part of the Bioprocess Commercial Organization located in the Central US region and will be fully remote.
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Design, optimize, and scale-up downstream processes for the purification of viral vectors, with a focus on AAV and lentiviral vectors. Proven expertise in downstream process development for viral vectors, with a focus on AAV and lentiviral vectors.
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The Senior Scientist I will play a key role in the developing downstream purification process development for various modalities such as mAbs, ADCs, bio-specifics, gene therapy, etc. Build experimentally verified fit for purpose mathematical models for downstream purification processes.
ExpandApply NowActive JobUpdated 9 days ago - UpvoteDownvoteShare Job
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In this vital role you will lead a Downstream Process engineering team at our Rhode Island Site. The Senior Manager will lead a team focused on bioprocess purification processes, drug substance manufacturing support and technology transfer of new products into the facilities.
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Reporting to the Pilot Plant Manager, the Pilot Plant Associate will participate in upstream and downstream areas of AAV development in the Pilot Plant for new gene therapy programs and processes.
ExpandApply NowActive JobUpdated 3 days ago - UpvoteDownvoteShare Job
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Experience with mammalian, insect, yeast, or bacterial cell lines and their cultivation and/or purification of biologics or viral vectors produced from such preferred. The Manufacturing Supervisor may be assigned to work directly with Upstream, Downstream or Buffer Preparation Unit Operations.
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Actively working in a bioprocess development environment in downstream processing of therapeutic antibodies, which includes, execution of experiments, developing new technologies, using standard and innovative techniques to purify proteins (Chromatography, filtration, use of robotic tools to understand molecule-specific behaviors during purification processes), as well as analytical techniques and analytical skills to interpret results.
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As a scientist in the Purification Development group, you will identify and develop new purification technologies, work to design optimized downstream drug substance processes for new biologic candidates, employ strategic thinking to overcome technical hurdles and oversee process technical transfer to GMP manufacturing facilities, as they make their way from discovery to the clinic and eventually commercialization.
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Product recovery, downstream purification as well as provide CMC support for external clients. Process development and manufacturing experience includes mammalian and/or microbial cell culture and scale up, the isolation and purification of proteins, antibodies, etc., extensive experience with product recovery (depth filtration, centrifugation, MF), TFF (UF/DF), chromatography (Affinity, IonX, HPT, HIC.
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Operate and maintain automated liquid handlers for plasmid purification, as well as downstream QC applications like NGS and DNA normalizations. Job Description: BioMedicine Design (BMD) is seeking a highly motivated Biochemist/Molecular Biologist to join Biotherapeutic Expression and Purification group (BEP) in Cambridge, MA. Qualified candidate will play an essential role in a high-energy DNA production and protein expression research laboratory.
ExpandApply NowActive JobUpdated 4 days ago
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